RRC ID 15574
著者 Ishida Y, Sekine Y, Oguchi H, Chihara T, Miura M, Ichijo H, Takeda K.
タイトル Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster.
ジャーナル PLoS One
Abstract The heat shock (HS) response is essential for survival of all organisms. Although the machinery of the HS response has been extensively investigated at the cellular level, it is poorly understood at the level of the organism. Here, we show the crucial role of the mushroom body (MB) in the HS response in Drosophila. Null mutants of the mitochondrial phosphatase Drosophila PGAM5 (dPGAM5) exhibited increased vulnerability to HS, which was reversed by MB-specific expression of the caspase inhibitor p35, and similar vulnerability was induced in wild-type flies by knockdown of MB dPGAM5. Elimination of the MB did not affect the HS response of wild-type flies, but did increase the resistance of dPGAM5-deficient flies to HS. Thus, the MB may possess an apoptosis-dependent toxic function, the suppression of which by dPGAM5 appears to be crucial for HS resistance.
巻・号 7(2)
ページ e30265
公開日 2012-2-7
DOI 10.1371/journal.pone.0030265
PII PONE-D-11-12088
PMID 22347370
PMC PMC3274544
MeSH Animals Apoptosis* Drosophila Proteins / physiology* Drosophila melanogaster / cytology Drosophila melanogaster / enzymology* Heat-Shock Response* Mitochondrial Proteins Mushroom Bodies / chemistry* Phosphoprotein Phosphatases / physiology*
IF 2.74
引用数 12
WOS 分野 NEUROSCIENCES
リソース情報
ショウジョウバエ 14816R-6 DGRC#109843 DGRC#109844