論文 - 詳細
| RRC ID | 15611 |
|---|---|
| 著者 | Komaki N, Watanabe T, Ogasawara A, Sato N, Mikami T, Matsumoto T. |
| タイトル | Antifungal mechanism of hinokitiol against Candida albicans. |
| ジャーナル | Biol Pharm Bull |
| Abstract |
The growth of Candida albicans was dose-dependently inhibited by addition of hinokitiol. The sensitivity of C. albicans to hinokitiol under aerobic conditions was higher than that under anaerobic conditions. Amount of ATP in C. albicans was not inhibited by hinokitiol under both conditions. The expression of mRNAs related to the growth signal, CYR1 and RAS1, was inhibited by hinokitiol. These findings suggested that the growth inhibition of C. albicans by hinokitiol was due to the interruption of RAS-signal transmission, such as the cAMP pathway. |
| 巻・号 | 31(4) |
| ページ | 735-7 |
| 公開日 | 2008-4-1 |
| DOI | 10.1248/bpb.31.735 |
| PII | JST.JSTAGE/bpb/31.735 |
| PMID | 18379073 |
| MeSH | Adenosine Triphosphate / metabolism Aerobiosis Antifungal Agents / pharmacology* Candida albicans / drug effects* Candida albicans / growth & development Candida albicans / metabolism Indicators and Reagents Microbial Sensitivity Tests Monoterpenes / pharmacology* RNA, Fungal / biosynthesis RNA, Fungal / genetics RNA, Messenger / biosynthesis RNA, Messenger / genetics Signal Transduction / drug effects Tropolone / analogs & derivatives* Tropolone / pharmacology |
| IF | 1.863 |
| 引用数 | 25 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1542 JCM 2074 JCM 2076 |