RRC ID |
15652
|
著者 |
Nishida S, Michinaka A, Nakashima K, Iino H, Fujii T.
|
タイトル |
Evaluation of the probiotic potential of Lactobacillus paracasei KW3110 based on in vitro tests and oral administration tests in healthy adults.
|
ジャーナル |
J Gen Appl Microbiol
|
Abstract |
Lactobacillus paracasei KW3110 is a strain which has been reported to possess a strong antiallergic activity. Since many lactic acid bacteria have shown to be useful as the probiotics, the possibility of this strain for use as a probiotic was studied. An in vitro test showed that this strain is strong enough to survive in the gastric juice. In addition, this strain showed exceptionally strong adherence to human intestinal epithelial cells, Caco-2 and HT29 compared to normal L. paracasei strains. Human oral administration testing of L. paracasei KW3110 showed that this strain survived in the human gut and increased the number of bifidobacteria and lactobacilli in the fecal samples of the subjects. In addition, KW 3110 was detected in 50% of the subjects up to 1 week after the end of the administration test. These results showed that L. paracasei KW3110 has a strong ability to survive in and colonize the human gut and improve the human intestinal microflora.
|
巻・号 |
54(5)
|
ページ |
267-76
|
公開日 |
2008-10-1
|
DOI |
10.2323/jgam.54.267
|
PII |
JST.JSTAGE/jgam/54.267
|
PMID |
19029768
|
MeSH |
Administration, Oral
Adult
Anti-Allergic Agents* / administration & dosage
Bacterial Adhesion
Bifidobacterium / growth & development
Bifidobacterium / isolation & purification
Bile Acids and Salts / pharmacology
Caco-2 Cells / microbiology
Drug Resistance, Bacterial
Epithelial Cells / microbiology
Humans
Hydrogen-Ion Concentration
Intestines / cytology
Intestines / microbiology*
Lactobacillus / classification
Lactobacillus / drug effects
Lactobacillus / isolation & purification
Lactobacillus / physiology*
Probiotics / administration & dosage*
|
IF |
1.442
|
引用数 |
18
|
WOS 分野
|
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
MICROBIOLOGY
|
リソース情報 |
一般微生物 |
JCM 1131
JCM 1217 |