論文 - 詳細
| RRC ID | 15652 |
|---|---|
| 著者 | Nishida S, Michinaka A, Nakashima K, Iino H, Fujii T. |
| タイトル | Evaluation of the probiotic potential of Lactobacillus paracasei KW3110 based on in vitro tests and oral administration tests in healthy adults. |
| ジャーナル | J Gen Appl Microbiol |
| Abstract |
Lactobacillus paracasei KW3110 is a strain which has been reported to possess a strong antiallergic activity. Since many lactic acid bacteria have shown to be useful as the probiotics, the possibility of this strain for use as a probiotic was studied. An in vitro test showed that this strain is strong enough to survive in the gastric juice. In addition, this strain showed exceptionally strong adherence to human intestinal epithelial cells, Caco-2 and HT29 compared to normal L. paracasei strains. Human oral administration testing of L. paracasei KW3110 showed that this strain survived in the human gut and increased the number of bifidobacteria and lactobacilli in the fecal samples of the subjects. In addition, KW 3110 was detected in 50% of the subjects up to 1 week after the end of the administration test. These results showed that L. paracasei KW3110 has a strong ability to survive in and colonize the human gut and improve the human intestinal microflora. |
| 巻・号 | 54(5) |
| ページ | 267-76 |
| 公開日 | 2008-10-1 |
| DOI | 10.2323/jgam.54.267 |
| PII | JST.JSTAGE/jgam/54.267 |
| PMID | 19029768 |
| MeSH | Administration, Oral Adult Anti-Allergic Agents* / administration & dosage Bacterial Adhesion Bifidobacterium / growth & development Bifidobacterium / isolation & purification Bile Acids and Salts / pharmacology Caco-2 Cells / microbiology Drug Resistance, Bacterial Epithelial Cells / microbiology Humans Hydrogen-Ion Concentration Intestines / cytology Intestines / microbiology* Lactobacillus / classification Lactobacillus / drug effects Lactobacillus / isolation & purification Lactobacillus / physiology* Probiotics / administration & dosage* |
| IF | 1.442 |
| 引用数 | 18 |
| WOS 分野 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1131 JCM 1217 |