論文 - 詳細
| RRC ID | 15827 |
|---|---|
| 著者 | Sawai H, Na K, Sasaki N, Mimitsuka T, Minegishi S, Henmi M, Yamada K, Shimizu S, Yonehara T. |
| タイトル | Membrane-integrated fermentation system for improving the optical purity of D-lactic acid produced during continuous fermentation. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
This report describes the production of highly optically pure D-lactic acid by the continuous fermentation of Sporolactobacillus laevolacticus and S. inulinus, using a membrane-integrated fermentation (MFR) system. The optical purity of D-lactic acid produced by the continuous fermentation system was greater than that produced by batch fermentation; the maximum value for the optical purity of D-lactic acid reached 99.8% enantiomeric excess by continuous fermentation when S. leavolacticus was used. The volumetric productivity of the optically pure D-lactic acid was about 12 g/L/h, this being approximately 11-fold higher than that obtained by batch fermentation. An enzymatic analysis indicated that both S. laevolacticus and S. inulinus could convert L-lactic acid to D-lactic acid by isomerization after the late-log phase. These results provide evidence for an effective bio-process to produce D-lactic acid of greater optical purity than has conventionally been achieved to date. |
| 巻・号 | 75(12) |
| ページ | 2326-32 |
| 公開日 | 2011-1-1 |
| DOI | 10.1271/bbb.110486 |
| PII | JST.JSTAGE/bbb/110486 |
| PMID | 22146719 |
| MeSH | Bacillales / cytology* Bacillales / enzymology Bacillales / metabolism* Bioreactors / microbiology* Cell Membrane / metabolism* Fermentation* L-Lactate Dehydrogenase / metabolism Lactic Acid / biosynthesis* Lactic Acid / chemistry Lactobacillus / metabolism Optical Phenomena* Stereoisomerism |
| IF | 1.516 |
| 引用数 | 11 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY CHEMISTRY, APPLIED BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1012 JCM 1164 JCM 2513 JCM 2515 JCM 6014 JCM 6124 |