論文 - 詳細
| RRC ID | 167 |
|---|---|
| 著者 | Kurushima H, Ohno M, Miura T, Nakamura TY, Horie H, Kadoya T, Ooboshi H, Kitazono T, Ibayashi S, Iida M, Nakabeppu Y. |
| タイトル | Selective induction of DeltaFosB in the brain after transient forebrain ischemia accompanied by an increased expression of galectin-1, and the implication of DeltaFosB and galectin-1 in neuroprotection and neurogenesis. |
| ジャーナル | Cell Death Differ |
| Abstract |
Transient forebrain ischemia causes selective induction of DeltaFosB, an AP-1 (activator protein-1) subunit, in cells within the ventricle wall or those in the dentate gyrus in the rat brain prior to neurogenesis, followed by induction of nestin, a marker for neuronal precursor cells, or galectin-1, a beta-galactoside sugar-binding lectin. The adenovirus-mediated expression of FosB or DeltaFosB induced expression of nestin, glial fibrillary acidic protein and galectin-1 in rat embryonic cortical cells. DeltaFosB-expressing cells exhibited a significantly higher survival and proliferation after the withdrawal of B27 supplement than the control or FosB-expressing cells. The decline in the DeltaFosB expression in the survivors enhanced the MAP2 expression. The expression of DeltaFosB in cells within the ventricle wall of the rat brain also resulted in an elevated expression of nestin. We therefore conclude that DeltaFosB can promote the proliferation of quiescent neuronal precursor cells, thus enhancing neurogenesis after transient forebrain ischemia. |
| 巻・号 | 12(8) |
| ページ | 1078-96 |
| 公開日 | 2005-8-1 |
| DOI | 10.1038/sj.cdd.4401648 |
| PII | 4401648 |
| PMID | 15861185 |
| MeSH | Adenoviridae / genetics Animals Brain / metabolism* Cells, Cultured Cerebral Cortex / metabolism Embryo, Mammalian Galectin 1 / biosynthesis Galectin 1 / physiology* Glial Fibrillary Acidic Protein / biosynthesis Immunohistochemistry Intermediate Filament Proteins / biosynthesis Ischemic Attack, Transient / metabolism* Male Mice Microscopy, Confocal Microscopy, Fluorescence Nerve Tissue Proteins / biosynthesis Nestin Neurons / cytology Neurons / metabolism Proto-Oncogene Proteins c-fos / biosynthesis Proto-Oncogene Proteins c-fos / genetics Proto-Oncogene Proteins c-fos / physiology* Rabbits Rats Rats, Inbred SHR Reverse Transcriptase Polymerase Chain Reaction Transcription Factors / biosynthesis Transcription Factors / genetics Transcription Factors / physiology* |
| IF | 10.717 |
| 引用数 | 26 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ラット | |