| RRC ID |
167
|
| 著者 |
Kurushima H, Ohno M, Miura T, Nakamura TY, Horie H, Kadoya T, Ooboshi H, Kitazono T, Ibayashi S, Iida M, Nakabeppu Y.
|
| タイトル |
Selective induction of DeltaFosB in the brain after transient forebrain ischemia accompanied by an increased expression of galectin-1, and the implication of DeltaFosB and galectin-1 in neuroprotection and neurogenesis.
|
| ジャーナル |
Cell Death Differ
|
| Abstract |
Transient forebrain ischemia causes selective induction of DeltaFosB, an AP-1 (activator protein-1) subunit, in cells within the ventricle wall or those in the dentate gyrus in the rat brain prior to neurogenesis, followed by induction of nestin, a marker for neuronal precursor cells, or galectin-1, a beta-galactoside sugar-binding lectin. The adenovirus-mediated expression of FosB or DeltaFosB induced expression of nestin, glial fibrillary acidic protein and galectin-1 in rat embryonic cortical cells. DeltaFosB-expressing cells exhibited a significantly higher survival and proliferation after the withdrawal of B27 supplement than the control or FosB-expressing cells. The decline in the DeltaFosB expression in the survivors enhanced the MAP2 expression. The expression of DeltaFosB in cells within the ventricle wall of the rat brain also resulted in an elevated expression of nestin. We therefore conclude that DeltaFosB can promote the proliferation of quiescent neuronal precursor cells, thus enhancing neurogenesis after transient forebrain ischemia.
|
| 巻・号 |
12(8)
|
| ページ |
1078-96
|
| 公開日 |
2005-8-1
|
| DOI |
10.1038/sj.cdd.4401648
|
| PII |
4401648
|
| PMID |
15861185
|
| MeSH |
Adenoviridae / genetics
Animals
Brain / metabolism*
Cells, Cultured
Cerebral Cortex / metabolism
Embryo, Mammalian
Galectin 1 / biosynthesis
Galectin 1 / physiology*
Glial Fibrillary Acidic Protein / biosynthesis
Immunohistochemistry
Intermediate Filament Proteins / biosynthesis
Ischemic Attack, Transient / metabolism*
Male
Mice
Microscopy, Confocal
Microscopy, Fluorescence
Nerve Tissue Proteins / biosynthesis
Nestin
Neurons / cytology
Neurons / metabolism
Proto-Oncogene Proteins c-fos / biosynthesis
Proto-Oncogene Proteins c-fos / genetics
Proto-Oncogene Proteins c-fos / physiology*
Rabbits
Rats
Rats, Inbred SHR
Reverse Transcriptase Polymerase Chain Reaction
Transcription Factors / biosynthesis
Transcription Factors / genetics
Transcription Factors / physiology*
|
| IF |
10.717
|
| 引用数 |
26
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ラット |
|
