| RRC ID |
173
|
| 著者 |
Matsumoto M, Togashi H, Kaku A, Kanno M, Tahara K, Yoshioka M.
|
| タイトル |
Cortical GABAergic regulation of dopaminergic responses to psychological stress in the rat dorsolateral striatum.
|
| ジャーナル |
Synapse
|
| Abstract |
The present study was undertaken to examine the possible involvement of cortical gamma-aminobutyric acid (GABA) neuronal mechanisms in the regional differences of dopamine (DA) response to psychological stress: contextual fear conditioning (CFC) in the rat prefrontal cortex (PFC) and dorsolateral striatum (DLS). Rats that received five footshocks (shock intensity, 0.5 mA; shock duration, 2 sec) were subjected to CFC and dynamic changes in DA and GABA in both PFC and DLS were examined using dual-probe microdialysis. Extracellular levels of DA in the PFC were enhanced during exposure to CFC, whereas the levels in the DLS were not affected by this stimulus. Extracellular levels of GABA in the PFC, but not in the DLS, were markedly enhanced by CFC. Freezing behavior observed during exposure to CFC was attenuated by the GABA(A) receptor antagonist bicuculline (10(-3) M), which was perfused into the PFC. Intracortical application of bicuculline (10(-3) M) furthermore caused sustained increases in DA levels in the DLS by CFC. These data suggest that cortical GABA(A) receptors contribute to modulation of DA release in the DLS in response to CFC. Thus, the GABAergic neuronal system in the PFC appears to play a key role in the regional differences of the DAergic response to psychological stress.
|
| 巻・号 |
56(2)
|
| ページ |
117-21
|
| 公開日 |
2005-5-1
|
| DOI |
10.1002/syn.20131
|
| PMID |
15729738
|
| MeSH |
Analysis of Variance
Animals
Behavior, Animal
Bicuculline / pharmacology
Corpus Striatum / metabolism*
Corpus Striatum / radiation effects
Dopamine / metabolism*
Dose-Response Relationship, Drug
Electroshock / adverse effects
Extracellular Space / drug effects
Extracellular Space / metabolism
Extracellular Space / radiation effects
Freezing Reaction, Cataleptic / drug effects
Freezing Reaction, Cataleptic / physiology
Freezing Reaction, Cataleptic / radiation effects
GABA Antagonists / pharmacology
Male
Microdialysis / methods
Prefrontal Cortex / drug effects
Prefrontal Cortex / metabolism
Prefrontal Cortex / radiation effects
Rats
Rats, Wistar
Stress, Psychological / etiology
Stress, Psychological / metabolism*
Time Factors
gamma-Aminobutyric Acid / physiology*
|
| IF |
2.318
|
| 引用数 |
16
|
|
WOS 分野
|
NEUROSCIENCES
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| リソース情報 |
| ラット |
|
