Reference - Detail
| RRC ID | 17548 |
|---|---|
| Author | McCairn KW, Iriki A, Isoda M. |
| Title | High-frequency pallidal stimulation eliminates tic-related neuronal activity in a nonhuman primate model of Tourette syndrome. |
| Journal | Neuroreport |
| Abstract |
High-frequency deep brain stimulation targeting the output nucleus of the basal ganglia, the globus pallidus internus, has been suggested as a treatment modality for intractable Tourette syndrome and basal-ganglia-mediated motor tics. Recent studies on the modeling of motor tics induced by focal injections of bicuculline to the striatum, a putative model of Tourette syndrome, have shown that tics induce a widespread modulation within both segments of the globus pallidus. The purpose of this study was to investigate, using the bicuculline-induced Tourette syndrome model, whether and how high-frequency deep brain stimulation targeted to the globus pallidus internus could modulate tic-related activity in the pallidum. The perievent rate changes coinciding with tic expression under the on-stimulation and off-stimulation conditions were examined to determine the effect of high-frequency stimulation on pallidal activity. The results showed that the stimulation blocked tic-related phasic changes in the firing pattern of pallidal cells in parallel with a reduction of the peak amplitude of tic events in the electromyography record. This finding supports the premise that deep brain stimulation targeted to the globus pallidus internus could be a viable treatment option for Tourette syndrome, and the use of pallidal stimulation for motor tics warrants further study. |
| Volume | 23(4) |
| Pages | 206-10 |
| Published | 2012-3-7 |
| DOI | 10.1097/WNR.0b013e32834fab9d |
| PMID | 22198687 |
| MeSH | Animals Deep Brain Stimulation / methods* Disease Models, Animal Globus Pallidus / physiology Globus Pallidus / surgery* Macaca mulatta Male Neurons / pathology* Tics / physiopathology Tics / prevention & control Tics / therapy* Tourette Syndrome / pathology Tourette Syndrome / therapy* Treatment Outcome |
| IF | 1.394 |
| Times Cited | 13 |
| WOS Category | NEUROSCIENCES |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Japanese macaques | |