論文 - 詳細
| RRC ID | 17548 |
|---|---|
| 著者 | McCairn KW, Iriki A, Isoda M. |
| タイトル | High-frequency pallidal stimulation eliminates tic-related neuronal activity in a nonhuman primate model of Tourette syndrome. |
| ジャーナル | Neuroreport |
| Abstract |
High-frequency deep brain stimulation targeting the output nucleus of the basal ganglia, the globus pallidus internus, has been suggested as a treatment modality for intractable Tourette syndrome and basal-ganglia-mediated motor tics. Recent studies on the modeling of motor tics induced by focal injections of bicuculline to the striatum, a putative model of Tourette syndrome, have shown that tics induce a widespread modulation within both segments of the globus pallidus. The purpose of this study was to investigate, using the bicuculline-induced Tourette syndrome model, whether and how high-frequency deep brain stimulation targeted to the globus pallidus internus could modulate tic-related activity in the pallidum. The perievent rate changes coinciding with tic expression under the on-stimulation and off-stimulation conditions were examined to determine the effect of high-frequency stimulation on pallidal activity. The results showed that the stimulation blocked tic-related phasic changes in the firing pattern of pallidal cells in parallel with a reduction of the peak amplitude of tic events in the electromyography record. This finding supports the premise that deep brain stimulation targeted to the globus pallidus internus could be a viable treatment option for Tourette syndrome, and the use of pallidal stimulation for motor tics warrants further study. |
| 巻・号 | 23(4) |
| ページ | 206-10 |
| 公開日 | 2012-3-7 |
| DOI | 10.1097/WNR.0b013e32834fab9d |
| PMID | 22198687 |
| MeSH | Animals Deep Brain Stimulation / methods* Disease Models, Animal Globus Pallidus / physiology Globus Pallidus / surgery* Macaca mulatta Male Neurons / pathology* Tics / physiopathology Tics / prevention & control Tics / therapy* Tourette Syndrome / pathology Tourette Syndrome / therapy* Treatment Outcome |
| IF | 1.394 |
| 引用数 | 13 |
| WOS 分野 | NEUROSCIENCES |
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| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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