| RRC ID |
17590
|
| 著者 |
Honda Y, Higashibata A, Matsunaga Y, Yonezawa Y, Kawano T, Higashitani A, Kuriyama K, Shimazu T, Tanaka M, Szewczyk NJ, Ishioka N, Honda S.
|
| タイトル |
Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans.
|
| ジャーナル |
Sci Rep
|
| Abstract |
How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that were down-regulated in space extended lifespan on the ground. These genes encode proteins that are likely related to neuronal or endocrine signaling: acetylcholine receptor, acetylcholine transporter, choline acetyltransferase, rhodopsin-like receptor, glutamate-gated chloride channel, shaker family of potassium channel, and insulin-like peptide. Most of them mediated lifespan control through the key longevity-regulating transcription factors DAF-16 or SKN-1 or through dietary-restriction signaling, singly or in combination. These results suggest that aging in C. elegans is slowed through neuronal and endocrine response to space environmental cues.
|
| 巻・号 |
2
|
| ページ |
487
|
| 公開日 |
2012-1-1
|
| DOI |
10.1038/srep00487
|
| PII |
srep00487
|
| PMID |
22768380
|
| PMC |
PMC3390002
|
| MeSH |
Animals
Animals, Genetically Modified
Caenorhabditis elegans / genetics
Caenorhabditis elegans / physiology*
Endocrine Cells / metabolism
Gene Expression Regulation*
Longevity / genetics*
Male
Models, Biological
Mutation
Neurons / metabolism
Pheromones / metabolism
RNA Interference
Signal Transduction
Space Flight*
Weightlessness
|
| IF |
3.998
|
| 引用数 |
25
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| 線虫 |
tm4341 |
