論文 - 詳細
| RRC ID | 17590 |
|---|---|
| 著者 | Honda Y, Higashibata A, Matsunaga Y, Yonezawa Y, Kawano T, Higashitani A, Kuriyama K, Shimazu T, Tanaka M, Szewczyk NJ, Ishioka N, Honda S. |
| タイトル | Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans. |
| ジャーナル | Sci Rep |
| Abstract |
How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that were down-regulated in space extended lifespan on the ground. These genes encode proteins that are likely related to neuronal or endocrine signaling: acetylcholine receptor, acetylcholine transporter, choline acetyltransferase, rhodopsin-like receptor, glutamate-gated chloride channel, shaker family of potassium channel, and insulin-like peptide. Most of them mediated lifespan control through the key longevity-regulating transcription factors DAF-16 or SKN-1 or through dietary-restriction signaling, singly or in combination. These results suggest that aging in C. elegans is slowed through neuronal and endocrine response to space environmental cues. |
| 巻・号 | 2 |
| ページ | 487 |
| 公開日 | 2012-1-1 |
| DOI | 10.1038/srep00487 |
| PII | srep00487 |
| PMID | 22768380 |
| PMC | PMC3390002 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Endocrine Cells / metabolism Gene Expression Regulation* Longevity / genetics* Male Models, Biological Mutation Neurons / metabolism Pheromones / metabolism RNA Interference Signal Transduction Space Flight* Weightlessness |
| IF | 3.998 |
| 引用数 | 25 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 76 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4341 |