Reference - Detail
| RRC ID | 17612 |
|---|---|
| Author | Takadera T, Koriyama Y, Kimura T, Kato S. |
| Title | 5-S-GAD attenuates Fe²+-induced lipid peroxidation and cell death in a neuronal cell model. |
| Journal | Neurotox Res |
| Abstract |
Iron accumulation in brain is associated with a number of common neurodegenerative disorders. N-β-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine (5-S-GAD), a novel catechol derivative, was isolated from adult flesh fly as a defense substance. We examined the effect of 5-S-GAD on Fe²+-induced lipid peroxidation and cell death in PC12 cells. Treatment of PC12 cells with Fe²+ (1-20 μM) for 24 h induced lipid peroxidation and cell death in a dose-dependent manner. Butylated hydroxyanisole and α-tocopherol inhibited Fe²+-induced lipid peroxidation and cell death. 5-S-GAD inhibited Fe²+-induced lipid peroxidation and cell death. 5-S-GAD protected PC12 cells from Fe²+-induced cell death possibly by blocking lipid peroxidation. |
| Volume | 20(1) |
| Pages | 26-31 |
| Published | 2011-7-1 |
| DOI | 10.1007/s12640-010-9218-7 |
| PMID | 20809179 |
| MeSH | Animals Butylated Hydroxyanisole / pharmacology Cell Death / drug effects* Cell Death / physiology Dihydroxyphenylalanine / analogs & derivatives* Dihydroxyphenylalanine / pharmacology Dose-Response Relationship, Drug Ferrous Compounds / antagonists & inhibitors* Ferrous Compounds / pharmacology Glutathione / analogs & derivatives* Glutathione / pharmacology Lipid Peroxidation / drug effects* Neurons / drug effects Neurons / physiology* PC12 Cells Rats Thiobarbituric Acid Reactive Substances / metabolism Tocopherols / pharmacology |
| IF | 2.992 |
| Times Cited | 3 |
| WOS Category | NEUROSCIENCES |
| Resource | |
| Human and Animal Cells | PC-12(RCB0009) |