論文 - 詳細
RRC ID | 17612 |
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著者 | Takadera T, Koriyama Y, Kimura T, Kato S. |
タイトル | 5-S-GAD attenuates Fe²+-induced lipid peroxidation and cell death in a neuronal cell model. |
ジャーナル | Neurotox Res |
Abstract |
Iron accumulation in brain is associated with a number of common neurodegenerative disorders. N-β-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine (5-S-GAD), a novel catechol derivative, was isolated from adult flesh fly as a defense substance. We examined the effect of 5-S-GAD on Fe²+-induced lipid peroxidation and cell death in PC12 cells. Treatment of PC12 cells with Fe²+ (1-20 μM) for 24 h induced lipid peroxidation and cell death in a dose-dependent manner. Butylated hydroxyanisole and α-tocopherol inhibited Fe²+-induced lipid peroxidation and cell death. 5-S-GAD inhibited Fe²+-induced lipid peroxidation and cell death. 5-S-GAD protected PC12 cells from Fe²+-induced cell death possibly by blocking lipid peroxidation. |
巻・号 | 20(1) |
ページ | 26-31 |
公開日 | 2011-7-1 |
DOI | 10.1007/s12640-010-9218-7 |
PMID | 20809179 |
MeSH | Animals Butylated Hydroxyanisole / pharmacology Cell Death / drug effects* Cell Death / physiology Dihydroxyphenylalanine / analogs & derivatives* Dihydroxyphenylalanine / pharmacology Dose-Response Relationship, Drug Ferrous Compounds / antagonists & inhibitors* Ferrous Compounds / pharmacology Glutathione / analogs & derivatives* Glutathione / pharmacology Lipid Peroxidation / drug effects* Neurons / drug effects Neurons / physiology* PC12 Cells Rats Thiobarbituric Acid Reactive Substances / metabolism Tocopherols / pharmacology |
IF | 2.992 |
引用数 | 3 |
WOS 分野 | NEUROSCIENCES |
リソース情報 | |
ヒト・動物細胞 | PC-12(RCB0009) |