RRC ID 17645
著者 Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S.
タイトル Expression of BMP-7 in human gastric cancer and its clinical significance.
ジャーナル Br J Cancer
Abstract BACKGROUND:Bone morphogenetic protein-7 (BMP-7) is a signalling molecule belonging to the transforming growth factor--superfamily. Recent studies have demonstrated the clinical impact of BMP-7 expression in various human cancers. However, there have been few reports detailing this in gastric cancer.
METHODS:We immunohistochemically investigated the expression of BMP-7 in 233 gastric cancer patients to disclose the clinicopathological features of BMP-7-positive gastric cancer.
RESULTS:Immunohistochemically, in human gastric cancer, BMP-7 expression was identified in cellular membranes but also in the cytoplasm of cancer cells. Bone morphogenetic protein-7-positive expression was found in 129 of 233 patients (55%). Bone morphogenetic protein-7 expression was correlated with tumour size, nodal involvement, lymphatic invasion, venous invasion and histology (P<0.05). Bone morphogenetic protein-7 expression was significantly correlated with patient postoperative outcome, especially in the undifferentiated group. Multivariate analysis revealed BMP-7 expression as one of the independent prognostic factors next to the depth of invasion and nodal involvement (P<0.01).
CONCLUSIONS:From the data collected, it would be appropriate to conclude on the possible regulation of gastric cancer progression by autocrine or paracrine BMP-7 loops. We can use BMP-7 expression as one of the strong predictors of risk of tumour recurrence in gastric cancer.
巻・号 104(4)
ページ 714-8
公開日 2011-2-15
DOI 10.1038/sj.bjc.6606075
PII 6606075
PMID 21224856
PMC PMC3049585
MeSH Adult Aged Aged, 80 and over Biomarkers, Tumor / analysis Biomarkers, Tumor / metabolism Bone Morphogenetic Protein 7 / metabolism* Bone Morphogenetic Protein 7 / physiology* Carcinoma / diagnosis* Carcinoma / metabolism* Carcinoma / pathology Carcinoma / surgery Cell Line, Tumor Disease Progression Female Humans Male Middle Aged Neoplasm Metastasis Neoplasm Recurrence, Local / diagnosis Neoplasm Recurrence, Local / metabolism Prognosis Stomach Neoplasms / diagnosis* Stomach Neoplasms / metabolism* Stomach Neoplasms / pathology Stomach Neoplasms / surgery Treatment Outcome Tumor Burden
IF 5.791
引用数 37
WOS 分野 ONCOLOGY
リソース情報
ヒト・動物細胞 Kato III(RCB2088) NUGC-4(RCB1939) MKN7(RCB0999) MKN45(RCB1001) MKN74(RCB1002)