論文 - 詳細
| RRC ID | 17656 |
|---|---|
| 著者 | Nagashima H, Kushiro M, Nakagawa H. |
| タイトル | Nuclear factor-κB inhibitors alleviate nivalenol-induced cytotoxicity in HL60 cells. |
| ジャーナル | Environ Toxicol Pharmacol |
| Abstract |
Tricothecene mycotoxins, such as nivalenol, are toxic to leukocytes. To elucidate the molecular mechanism of nivalenol toxicity, we investigated the involvement of nuclear factor-κB (NF-κB) in nivalenol-induced cytotoxicity in HL60 cells using the NF-κB inhibitors pyrrolidinedithiocarbamate (PDTC) and dexamethasone. Cells were treated with the chemicals for 24h before assays were performed. Nivalenol elicited interleukin (IL)-8 secretion. IL-8 secretion was lower in cells concomitantly treated with nivalenol and NF-κB inhibitors than with nivalenol alone. Nivalenol reduced monocyte chemotactic protein (MCP)-1 secretion. MCP-1 secretion was higher in cells concomitantly treated with nivalenol and NF-κB inhibitors than with nivalenol alone. NF-κB inhibitors thus alleviated the effects of nivalenol, indicating that NF-κB is important for nivalenol-caused changes in cytokine secretion. Nivalenol hindered cell proliferation, and dexamethasone reduced this effect, suggesting that NF-κB contributes to cell proliferation. Thus, it appears that NF-κB is involved in nivalenol-induced toxicity in HL60 cells. |
| 巻・号 | 31(1) |
| ページ | 258-61 |
| 公開日 | 2011-1-1 |
| DOI | 10.1016/j.etap.2010.09.014 |
| PII | S1382-6689(10)00171-7 |
| PMID | 21787693 |
| MeSH | Anti-Inflammatory Agents / pharmacology Antioxidants / pharmacology Cell Proliferation / drug effects Cell Survival / drug effects Chemokine CCL2 / metabolism Cytokines / metabolism Dexamethasone / pharmacology HL-60 Cells Humans Interleukin-8 / metabolism Mycotoxins / antagonists & inhibitors* Mycotoxins / toxicity NF-kappa B / antagonists & inhibitors NF-kappa B / physiology* Proline / analogs & derivatives Proline / pharmacology Thiocarbamates / pharmacology Trichothecenes / antagonists & inhibitors* Trichothecenes / toxicity* |
| IF | 3.292 |
| 引用数 | 7 |
| WOS 分野 | PHARMACOLOGY & PHARMACY ENVIRONMENTAL SCIENCES TOXICOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | HL60(RCB0041) |