RRC ID 1792
Author Kusama S, Ueda R, Suda T, Nishihara S, Matsuura ET.
Title Involvement of Drosophila Sir2-like genes in the regulation of life span.
Journal Genes Genet. Syst.
Abstract In Drosophila melanogaster, the Sir2 gene and four Sir2-like genes have been found to be homologous to yeast SIR2 genes. To examine whether the fly Sir2, CG5216, and two Sir2-like genes, CG5085 and CG6284, affect life span, we suppressed their expression using RNAi. Decreased expression of the Sir2 and Sir2-like genes in all cells caused lethality during development. Suppression of the Sir2 in neurons and ubiquitous silencing of the Sir2-like genes shortened life spans. The effects were severer at 28 degrees C than at 25 degrees C. These results suggest that Sir2-like genes as well as Sir2 are involved in the regulation of life span in Drosophila.
Volume 81(5)
Pages 341-8
Published 2006-10
PII JST.JSTAGE/ggs/81.341
PMID 17159295
MeSH Animals Drosophila Proteins / genetics* Drosophila melanogaster / genetics* Drosophila melanogaster / physiology Histone Deacetylases / genetics* Longevity / genetics* Sirtuins / genetics*
IF 0.859
Times Cited 12
Drosophila 5216R-1 5216R-2 6824R-1 6824R-2 5085R-3 5085R-5 6284R-2 6284R-4