RRC ID 18555
著者 Du G, Kataoka K, Sakaguchi M, Abarzua F, Than SS, Sonegawa H, Makino T, Shimizu T, Huh NH.
タイトル Expression of REIC/Dkk-3 in normal and hyperproliferative epidermis.
ジャーナル Exp Dermatol
Abstract Dickkopf (Dkk) family members are known as Wnt modulators involved in the development, cell growth/differentiation and cancer. REIC/Dkk-3, which does not interfere with Wnt signalling, has been proposed to be a tumor suppressor gene, but its physiological function has remained unclear. In this study, we analysed the expression of REIC/Dkk-3 in normal interfollicular epidermis (IFE) and hyperproliferative epidermis. REIC/Dkk-3 was expressed in human and mouse IFE, being localized at the interface of upper spinous layer and granular layer. Skin cancer cell lines lost REIC/Dkk-3 expression as reported previously. When we analysed patient samples, REIC/Dkk-3 expression was down-regulated in the hyperproliferative epidermis including skin cancers and non-cancerous proliferative diseases. REIC/Dkk-3 expression was also suppressed in the regenerative and inflammative epidermis of model mice. These findings will certainly contribute to the extension of studies on REIC/Dkk-3.
巻・号 20(3)
ページ 273-7
公開日 2011-3-1
DOI 10.1111/j.1600-0625.2010.01244.x
PMID 21323747
MeSH Adaptor Proteins, Signal Transducing Animals Cell Line, Tumor Chemokines Down-Regulation / physiology Embryo, Mammalian / metabolism Epidermis / embryology Epidermis / metabolism* Hair Follicle / metabolism Humans Inflammation / chemically induced Inflammation / metabolism Intercellular Signaling Peptides and Proteins / metabolism* Keratosis / metabolism* Male Mice Mice, Inbred BALB C Skin Diseases, Papulosquamous / metabolism* Skin Neoplasms / metabolism* Tetradecanoylphorbol Acetate / pharmacology Wound Healing / physiology
IF 3.368
引用数 11
WOS 分野 DERMATOLOGY
リソース情報
ヒト・動物細胞 BSCC-93(RCB1202)