RRC ID |
18555
|
著者 |
Du G, Kataoka K, Sakaguchi M, Abarzua F, Than SS, Sonegawa H, Makino T, Shimizu T, Huh NH.
|
タイトル |
Expression of REIC/Dkk-3 in normal and hyperproliferative epidermis.
|
ジャーナル |
Exp Dermatol
|
Abstract |
Dickkopf (Dkk) family members are known as Wnt modulators involved in the development, cell growth/differentiation and cancer. REIC/Dkk-3, which does not interfere with Wnt signalling, has been proposed to be a tumor suppressor gene, but its physiological function has remained unclear. In this study, we analysed the expression of REIC/Dkk-3 in normal interfollicular epidermis (IFE) and hyperproliferative epidermis. REIC/Dkk-3 was expressed in human and mouse IFE, being localized at the interface of upper spinous layer and granular layer. Skin cancer cell lines lost REIC/Dkk-3 expression as reported previously. When we analysed patient samples, REIC/Dkk-3 expression was down-regulated in the hyperproliferative epidermis including skin cancers and non-cancerous proliferative diseases. REIC/Dkk-3 expression was also suppressed in the regenerative and inflammative epidermis of model mice. These findings will certainly contribute to the extension of studies on REIC/Dkk-3.
|
巻・号 |
20(3)
|
ページ |
273-7
|
公開日 |
2011-3-1
|
DOI |
10.1111/j.1600-0625.2010.01244.x
|
PMID |
21323747
|
MeSH |
Adaptor Proteins, Signal Transducing
Animals
Cell Line, Tumor
Chemokines
Down-Regulation / physiology
Embryo, Mammalian / metabolism
Epidermis / embryology
Epidermis / metabolism*
Hair Follicle / metabolism
Humans
Inflammation / chemically induced
Inflammation / metabolism
Intercellular Signaling Peptides and Proteins / metabolism*
Keratosis / metabolism*
Male
Mice
Mice, Inbred BALB C
Skin Diseases, Papulosquamous / metabolism*
Skin Neoplasms / metabolism*
Tetradecanoylphorbol Acetate / pharmacology
Wound Healing / physiology
|
IF |
3.368
|
引用数 |
11
|
WOS 分野
|
DERMATOLOGY
|
リソース情報 |
ヒト・動物細胞 |
BSCC-93(RCB1202) |