論文 - 詳細
| RRC ID | 18697 |
|---|---|
| 著者 | Saito M, Yaguchi T, Yasuda Y, Nakano T, Nishizaki T. |
| タイトル | Adenosine suppresses CW2 human colonic cancer growth by inducing apoptosis via A(1) adenosine receptors. |
| ジャーナル | Cancer Lett |
| Abstract |
Extracellular adenosine-induced apoptosis of CW2 human colonic cancer cells by activating caspase-3, -8 and -9, and the effect was enhanced by adding EHNA, an adenosine deaminase inhibitor. Adenosine-induced CW2 cell death was inhibited by 8-CPT, an A(1) adenosine receptor inhibitor, but otherwise 2-chloroadenosine, an A(1) adenosine receptor agonist, and MDL-12330A, an inhibitor of adenylate cyclase, mimicked the adenosine effect. For mice inoculated with CW2 cells, intraperitoneal injection with adenosine reduced tumor growth and more prominent reduction was obtained with co-injection with EHNA. Adenosine, thus, suppresses CW2 human colonic cancer growth by inducing apoptosis as mediated via A(1) adenosine receptors. |
| 巻・号 | 290(2) |
| ページ | 211-5 |
| 公開日 | 2010-4-28 |
| DOI | 10.1016/j.canlet.2009.09.011 |
| PII | S0304-3835(09)00599-0 |
| PMID | 19822392 |
| MeSH | Adenosine / pharmacology* Animals Antineoplastic Agents / pharmacology* Apoptosis / drug effects* Caspases / drug effects Caspases / metabolism Cell Line, Tumor Cell Proliferation / drug effects Colonic Neoplasms / metabolism Colonic Neoplasms / pathology* Enzyme Activation / drug effects Humans Mice Receptor, Adenosine A1 / drug effects* Receptor, Adenosine A1 / metabolism Reverse Transcriptase Polymerase Chain Reaction Xenograft Model Antitumor Assays |
| IF | 7.36 |
| 引用数 | 53 |
| WOS 分野 | ONCOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | CW-2(RCB0778) |