| RRC ID |
18933
|
| Author |
Lee JW, Ahn G, Kim JY, Cho DW.
|
| Title |
Evaluating cell proliferation based on internal pore size and 3D scaffold architecture fabricated using solid freeform fabrication technology.
|
| Journal |
J Mater Sci Mater Med
|
| Abstract |
The scaffold, as a medical component to regenerate tissues or organs in humans, plays an important role in tissue engineering. Recently, solid freeform fabrication (SFF) technology using computer-assisted methods was applied to address the problems of conventional fabrication methods in which the internal/outer architectures cannot be controlled. In this report, we propose suitable scaffolds for bone tissue regeneration considering the internal pore size and scaffold architecture. Poly(propylene fumarate) was used as the biodegradable photopolymer, and scaffolds were fabricated using microstereolithography (MSTL). We observed the relationship between the internal pores and architecture, and the proliferation of pre-osteoblast cells. To demonstrate the superiority of MSTL, we fabricated conventional and SFF scaffolds, and measured the cell proliferation rates for each. The results showed that cell proliferation on the MSTL scaffold was clearly superior and indicated that MSTL would be a good replacement for current conventional methods.
|
| Volume |
21(12)
|
| Pages |
3195-205
|
| Published |
2010-12-1
|
| DOI |
10.1007/s10856-010-4173-7
|
| PMID |
20981473
|
| MeSH |
Animals
Cell Proliferation*
Cells, Cultured
Humans
Manufactured Materials / analysis
Materials Testing / methods*
Mice
Microtechnology / methods*
Models, Biological
Particle Size
Porosity
Tissue Engineering / methods*
Tissue Scaffolds / chemistry*
|
| IF |
2.489
|
| Times Cited |
46
|
|
WOS Category
|
ENGINEERING, BIOMEDICAL
MATERIALS SCIENCE, BIOMATERIALS
|
| Resource |
| Human and Animal Cells |
MC3T3-E1(RCB1126) |
