論文 - 詳細
| RRC ID | 18933 |
|---|---|
| 著者 | Lee JW, Ahn G, Kim JY, Cho DW. |
| タイトル | Evaluating cell proliferation based on internal pore size and 3D scaffold architecture fabricated using solid freeform fabrication technology. |
| ジャーナル | J Mater Sci Mater Med |
| Abstract |
The scaffold, as a medical component to regenerate tissues or organs in humans, plays an important role in tissue engineering. Recently, solid freeform fabrication (SFF) technology using computer-assisted methods was applied to address the problems of conventional fabrication methods in which the internal/outer architectures cannot be controlled. In this report, we propose suitable scaffolds for bone tissue regeneration considering the internal pore size and scaffold architecture. Poly(propylene fumarate) was used as the biodegradable photopolymer, and scaffolds were fabricated using microstereolithography (MSTL). We observed the relationship between the internal pores and architecture, and the proliferation of pre-osteoblast cells. To demonstrate the superiority of MSTL, we fabricated conventional and SFF scaffolds, and measured the cell proliferation rates for each. The results showed that cell proliferation on the MSTL scaffold was clearly superior and indicated that MSTL would be a good replacement for current conventional methods. |
| 巻・号 | 21(12) |
| ページ | 3195-205 |
| 公開日 | 2010-12-1 |
| DOI | 10.1007/s10856-010-4173-7 |
| PMID | 20981473 |
| MeSH | Animals Cell Proliferation* Cells, Cultured Humans Manufactured Materials / analysis Materials Testing / methods* Mice Microtechnology / methods* Models, Biological Particle Size Porosity Tissue Engineering / methods* Tissue Scaffolds / chemistry* |
| IF | 2.489 |
| 引用数 | 46 |
| WOS 分野 | ENGINEERING, BIOMEDICAL MATERIALS SCIENCE, BIOMATERIALS |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |