| RRC ID |
1914
|
| Author |
Kumano Y, Sakamoto T, Egawa M, Iwai I, Tanaka M, Yamamoto I.
|
| Title |
In vitro and in vivo prolonged biological activities of novel vitamin C derivative, 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G), in cosmetic fields.
|
| Journal |
J Nutr Sci Vitaminol (Tokyo)
|
| Abstract |
The biological activity of the novel vitamin C derivative, 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G), was evaluated in vitro and in vivo. The percutaneous absorption of AA-2G was determined in five Japanese males. The excretion of ascorbic acid (AA) in the subjects administered AA-2G was sustained for a longer period than in the subjects administered ascorbic acid 2-phosphate (AA-2P), which is a conventional vitamin C derivative. An analysis of the distribution of AA in the skin showed that small black specks assumed to be AA were observed in the epidermis even 3 d after applying AA-2G. The melanin synthesis in B16 melanoma cells was inhibited more by AA-2G than by AA-2P, and AA-2G also prevented more UV-induced damage of human skin keratinocytes and fibroblasts than AA-2P did. From these in vivo and in vitro results, it is supposed that the conversion of AA-2G to AA is sustained for a long time compared with that of AA-2P, and that AA-2G is an effective and available compound having vitamin C activity in human subjects.
|
| Volume |
44(3)
|
| Pages |
345-59
|
| Published |
1998-6-1
|
| DOI |
10.3177/jnsv.44.345
|
| PMID |
9742456
|
| MeSH |
Absorption
Ascorbic Acid / analogs & derivatives*
Ascorbic Acid / analysis
Ascorbic Acid / metabolism
Ascorbic Acid / pharmacokinetics
Ascorbic Acid / pharmacology
Ascorbic Acid / therapeutic use
Cells, Cultured
Cosmetics*
Epidermis / metabolism
Humans
Hydroxyl Radical / metabolism
Keratinocytes / drug effects
Keratinocytes / radiation effects
Lipid Peroxidation / drug effects
Male
Melanins / biosynthesis
Melanoma / metabolism
Skin / chemistry
Skin / metabolism
Sunburn / prevention & control
Tissue Distribution
Tumor Cells, Cultured
Ultraviolet Rays
|
| IF |
1.424
|
| Resource |
| Human and Animal Cells |
NB1RGB(RCB0222) |
