| RRC ID |
19216
|
| 著者 |
Ishikawa K, Toyama-Sorimachi N, Nakada K, Morimoto M, Imanishi H, Yoshizaki M, Sasawatari S, Niikura M, Takenaga K, Yonekawa H, Hayashi J.
|
| タイトル |
The innate immune system in host mice targets cells with allogenic mitochondrial DNA.
|
| ジャーナル |
J Exp Med
|
| Abstract |
Mitochondrial DNA (mtDNA) has been proposed to be involved in respiratory function, and mtDNA mutations have been associated with aging, tumors, and various disorders, but the effects of mtDNA imported into transplants from different individuals or aged subjects have been unclear. We examined this issue by generating trans-mitochondrial tumor cells and embryonic stem cells that shared the syngenic C57BL/6 (B6) strain-derived nuclear DNA background but possessed mtDNA derived from allogenic mouse strains. We demonstrate that transplants with mtDNA from the NZB/B1NJ strain were rejected from the host B6 mice, not by the acquired immune system but by the innate immune system. This rejection was caused partly by NK cells and involved a MyD88-dependent pathway. These results introduce novel roles of mtDNA and innate immunity in tumor immunology and transplantation medicine.
|
| 巻・号 |
207(11)
|
| ページ |
2297-305
|
| 公開日 |
2010-10-25
|
| DOI |
10.1084/jem.20092296
|
| PII |
jem.20092296
|
| PMID |
20937705
|
| PMC |
PMC2964578
|
| MeSH |
Aging / genetics
Aging / immunology
Animals
Carcinoma, Lewis Lung / genetics
Carcinoma, Lewis Lung / immunology*
Cell Line, Tumor
DNA, Mitochondrial / genetics
DNA, Mitochondrial / immunology*
Embryonic Stem Cells / immunology*
Graft Rejection / genetics
Graft Rejection / immunology*
Immunity, Innate / physiology*
Killer Cells, Natural / immunology
Mice
Mice, Inbred NZB
Mutation
Myeloid Differentiation Factor 88 / genetics
Myeloid Differentiation Factor 88 / immunology
Neoplasm Transplantation
Stem Cell Transplantation*
Transplantation, Homologous
|
| IF |
11.743
|
| 引用数 |
26
|
|
WOS 分野
|
MEDICINE, RESEARCH & EXPERIMENTAL
IMMUNOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
B6G-2(AES0003) |
