論文 - 詳細
RRC ID | 19276 |
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著者 | Ng SS, Mahmoudi T, Danenberg E, Bejaoui I, de Lau W, Korswagen HC, Schutte M, Clevers H. |
タイトル | Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade. |
ジャーナル | J Biol Chem |
Abstract |
Mutational activation of the phosphatidylinositol 3-kinase (PI3K) pathway occurs in a wide variety of tumors, whereas activating Wnt pathway mutants are predominantly found in colon cancer. Because GSK3 is a key component of both pathways, it is widely assumed that active PI3K signaling feeds positively into the Wnt pathway by protein kinase B (PKB)-mediatefd inhibition of GSK3. In addition, PKB has been proposed to modulate the canonical Wnt signaling through direct stabilization and nuclear localization of beta-catenin. Here, we show that compartmentalization by Axin of GSK3 prohibits cross-talk between the PI3K and Wnt pathways and that Wnt-mediated transcriptional activity is not modulated by activation of the PI3K/PKB pathway. |
巻・号 | 284(51) |
ページ | 35308-13 |
公開日 | 2009-12-18 |
DOI | 10.1074/jbc.M109.078261 |
PII | S0021-9258(20)37495-0 |
PMID | 19850932 |
PMC | PMC2790960 |
MeSH | Active Transport, Cell Nucleus / physiology Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins Cell Line Cell Nucleus / genetics Cell Nucleus / metabolism* Enzyme Activation / physiology Humans Phosphatidylinositol 3-Kinases / genetics Phosphatidylinositol 3-Kinases / metabolism* Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-akt / genetics Proto-Oncogene Proteins c-akt / metabolism Signal Transduction / physiology* Transcription, Genetic / physiology Wnt Proteins / genetics Wnt Proteins / metabolism* beta Catenin / genetics beta Catenin / metabolism* |
IF | 4.238 |
引用数 | 31 |
WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
リソース情報 | |
ヒト・動物細胞 | OCUB-F(RCB0882) |