論文 - 詳細
| RRC ID | 19276 |
|---|---|
| 著者 | Ng SS, Mahmoudi T, Danenberg E, Bejaoui I, de Lau W, Korswagen HC, Schutte M, Clevers H. |
| タイトル | Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade. |
| ジャーナル | J Biol Chem |
| Abstract |
Mutational activation of the phosphatidylinositol 3-kinase (PI3K) pathway occurs in a wide variety of tumors, whereas activating Wnt pathway mutants are predominantly found in colon cancer. Because GSK3 is a key component of both pathways, it is widely assumed that active PI3K signaling feeds positively into the Wnt pathway by protein kinase B (PKB)-mediatefd inhibition of GSK3. In addition, PKB has been proposed to modulate the canonical Wnt signaling through direct stabilization and nuclear localization of beta-catenin. Here, we show that compartmentalization by Axin of GSK3 prohibits cross-talk between the PI3K and Wnt pathways and that Wnt-mediated transcriptional activity is not modulated by activation of the PI3K/PKB pathway. |
| 巻・号 | 284(51) |
| ページ | 35308-13 |
| 公開日 | 2009-12-18 |
| DOI | 10.1074/jbc.M109.078261 |
| PII | S0021-9258(20)37495-0 |
| PMID | 19850932 |
| PMC | PMC2790960 |
| MeSH | Active Transport, Cell Nucleus / physiology Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins Cell Line Cell Nucleus / genetics Cell Nucleus / metabolism* Enzyme Activation / physiology Humans Phosphatidylinositol 3-Kinases / genetics Phosphatidylinositol 3-Kinases / metabolism* Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-akt / genetics Proto-Oncogene Proteins c-akt / metabolism Signal Transduction / physiology* Transcription, Genetic / physiology Wnt Proteins / genetics Wnt Proteins / metabolism* beta Catenin / genetics beta Catenin / metabolism* |
| IF | 4.238 |
| 引用数 | 31 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | OCUB-F(RCB0882) |