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  • Search Condition : Filter (MeSH = Phosphatidylinositol 3-Kinases / genetics)
Species Resource Title
Human and Animal Cells NUGC-4(RCB1939) , MKN7(RCB0999) , MKN45(RCB1001) ARID1A deficiency is targetable by AKT inhibitors in HER2-negative gastric cancer.
Human and Animal Cells Lu-134-A(RCB0466) , Lu-134-B(RCB0467) Targeting small cell lung cancer harboring PIK3CA mutation with a selective oral PI3K inhibitor PF-4989216.
Human and Animal Cells MDCK(RCB0995) Down-regulation of Mcl-1 by inhibition of the PI3-K/Akt pathway is required for cell shrinkage-dependent cell death.
Human and Animal Cells NIH/3T3(RCB2767) KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice.
DNA material pEGFP-C1-hUVRAG (RDB19632) , pMXs-puro-VPS34-GFP (RDB19633) , p3xFLAG-CMV10-hUVRAG (RDB19776) , pEGFP-C1-hAtg14 (RDB19785) , pMXs-IP-GFP-Atg14 (RDB19790) , pCI-neo-HA-hAtg14 (RDB19797) , pCI-neo-HA-hUVRAG (RDB19803) Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.
Human and Animal Cells MKN45(RCB1001) , MKN74(RCB1002) Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil.
Human and Animal Cells Hep G2 (-)-Epigallocatechin-3-gallate Down-regulates Doxorubicin-induced Overexpression of P-glycoprotein Through the Coordinate Inhibition of PI3K/Akt and MEK/ERK Signaling Pathways.
Human and Animal Cells JHOC-5(RCB1520) A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation.
Yeast TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation.
Human and Animal Cells RAW 264(RCB0535) Macrophage-derived extracellular vesicles regulate concanavalin A-induced hepatitis by suppressing macrophage cytokine production.
Human and Animal Cells Ca9-22(RCB1976) , HSC-2(RCB1945) , HSC-4(RCB1902) , Sa3(RCB0980) , HSQ-89(RCB0789) , SAS(RCB1974) , HO-1-u-1(RCB2102) Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential.
Human and Animal Cells HSC-4(RCB1902) , SAS(RCB1974) , Ca9-22(RCB1976) Migration of oral squamous cell carcinoma cells are induced by HGF/c-Met signalling via lamellipodia and filopodia formation.
Human and Animal Cells HKBML(RCB0820) Metabolome Analysis Reveals Excessive Glycolysis via PI3K/AKT/mTOR and RAS/MAPK Signaling in Methotrexate-Resistant Primary CNS Lymphoma-Derived Cells.
Human and Animal Cells JHOC-5(RCB1520) , JHOC-7(RCB1688) , JHOC-8(RCB1723) , JHOC-9(RCB2226) Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis.
Human and Animal Cells HeLa(RCB0007) , Saos-2(RCB0428) Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways.
Human and Animal Cells iPS-MEF-Ng-20D-17(APS0001) Signaling Inhibitors Accelerate the Conversion of mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment.
Drosophila Ras2, the TC21/R-Ras2 Drosophila homologue, contributes to insulin signalling but is not required for organism viability.
Human and Animal Cells TE-1(RCB1894) , TE-8(RCB2098) , TE-10(RCB2099) , TE-11(RCB2100) B7H4 is associated with stemness and cancer progression in esophageal squamous cell carcinoma.
Human and Animal Cells A549 Decrease in paracellular permeability and chemosensitivity to doxorubicin by claudin-1 in spheroid culture models of human lung adenocarcinoma A549 cells.
Cellular slime molds Excitable dynamics of Ras triggers spontaneous symmetry breaking of PIP3 signaling in motile cells.