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  • Search Condition : Filter (MeSH = Phosphatidylinositol 3-Kinases / genetics)
Species Resource Title
Human and Animal Cells MDCK(RCB0995) Down-regulation of Mcl-1 by inhibition of the PI3-K/Akt pathway is required for cell shrinkage-dependent cell death.
Human and Animal Cells NIH/3T3(RCB2767) KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice.
DNA material pEGFP-C1-hUVRAG (RDB19632) , pMXs-puro-VPS34-GFP (RDB19633) , p3xFLAG-CMV10-hUVRAG (RDB19776) , pEGFP-C1-hAtg14 (RDB19785) , pMXs-IP-GFP-Atg14 (RDB19790) , pCI-neo-HA-hAtg14 (RDB19797) , pCI-neo-HA-hUVRAG (RDB19803) Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.
Human and Animal Cells MKN45(RCB1001) , MKN74(RCB1002) Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil.
Human and Animal Cells Hep G2 (-)-Epigallocatechin-3-gallate Down-regulates Doxorubicin-induced Overexpression of P-glycoprotein Through the Coordinate Inhibition of PI3K/Akt and MEK/ERK Signaling Pathways.
Human and Animal Cells JHOC-5(RCB1520) A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation.
Yeast TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation.
Human and Animal Cells RAW 264(RCB0535) Macrophage-derived extracellular vesicles regulate concanavalin A-induced hepatitis by suppressing macrophage cytokine production.
Human and Animal Cells Ca9-22(RCB1976) , HSC-2(RCB1945) , HSC-4(RCB1902) , Sa3(RCB0980) , HSQ-89(RCB0789) , SAS(RCB1974) , HO-1-u-1(RCB2102) Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential.
Human and Animal Cells HSC-4(RCB1902) , SAS(RCB1974) , Ca9-22(RCB1976) Migration of oral squamous cell carcinoma cells are induced by HGF/c-Met signalling via lamellipodia and filopodia formation.
Human and Animal Cells HKBML(RCB0820) Metabolome Analysis Reveals Excessive Glycolysis via PI3K/AKT/mTOR and RAS/MAPK Signaling in Methotrexate-Resistant Primary CNS Lymphoma-Derived Cells.
Human and Animal Cells JHOC-5(RCB1520) , JHOC-7(RCB1688) , JHOC-8(RCB1723) , JHOC-9(RCB2226) Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis.
Human and Animal Cells HeLa(RCB0007) , Saos-2(RCB0428) Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways.
Human and Animal Cells iPS-MEF-Ng-20D-17(APS0001) Signaling Inhibitors Accelerate the Conversion of mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment.
Drosophila Ras2, the TC21/R-Ras2 Drosophila homologue, contributes to insulin signalling but is not required for organism viability.
Human and Animal Cells TE-1(RCB1894) , TE-8(RCB2098) , TE-10(RCB2099) , TE-11(RCB2100) B7H4 is associated with stemness and cancer progression in esophageal squamous cell carcinoma.
Human and Animal Cells A549 Decrease in paracellular permeability and chemosensitivity to doxorubicin by claudin-1 in spheroid culture models of human lung adenocarcinoma A549 cells.
Cellular slime molds Excitable dynamics of Ras triggers spontaneous symmetry breaking of PIP3 signaling in motile cells.
Human and Animal Cells HSC-3(RCB1975) DKK3 knockdown confers negative effects on the malignant potency of head and neck squamous cell carcinoma cells via the PI3K/Akt and MAPK signaling pathways.
Human and Animal Cells MH7A(RCB1512) miR-145 eliminates lipopolysaccharides-induced inflammatory injury in human fibroblast-like synoviocyte MH7A cells.