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  • Search Condition : Filter (MeSH = Phosphatidylinositol 3-Kinases / genetics)
Species Resource
Human and Animal Cells TE-1(RCB1894) , TE-8(RCB2098) , TE-10(RCB2099) , TE-11(RCB2100) B7H4 is associated with stemness and cancer progression in esophageal squamous cell carcinoma.
Human and Animal Cells A549 Decrease in paracellular permeability and chemosensitivity to doxorubicin by claudin-1 in spheroid culture models of human lung adenocarcinoma A549 cells.
Human and Animal Cells HSC-3(RCB1975) DKK3 knockdown confers negative effects on the malignant potency of head and neck squamous cell carcinoma cells via the PI3K/Akt and MAPK signaling pathways.
Human and Animal Cells MRC-5(RCB0211) Resistance mediated by alternative receptor tyrosine kinases in FGFR1-amplified lung cancer.
Human and Animal Cells CACO-2(RCB0988) Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-κB signaling pathway in secondary hyperparathyroidism.
Human and Animal Cells MKN1(RCB1003) Analysis of PIK3CA mutations and PI3K pathway proteins in advanced gastric cancer.
Human and Animal Cells MKN1(RCB1003) , MKN45(RCB1001) , MKN7(RCB0999) , MKN74(RCB1002) PTEN loss is associated with a poor response to trastuzumab in HER2-overexpressing gastroesophageal adenocarcinoma.
Mice C57BL/6-Tg(CAG-flpe)36Ito/ItoRbrc(RBRC01834) Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia.
C.elegans tm3536 , tm3645 Depletion of mboa-7, an enzyme that incorporates polyunsaturated fatty acids into phosphatidylinositol (PI), impairs PI 3-phosphate signaling in Caenorhabditis elegans.
C.elegans tm331 , tm420 DAF-16 and Δ9 desaturase genes promote cold tolerance in long-lived Caenorhabditis elegans age-1 mutants.
C.elegans tm4475 PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation.
C.elegans tm1956 The insulin/IGF signaling regulators cytohesin/GRP-1 and PIP5K/PPK-1 modulate susceptibility to excitotoxicity in C. elegans.
C.elegans tm718 Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans.
C.elegans tm2423 PtdIns(4,5)P₂ and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance.
Human and Animal Cells Examination of a Viral Infection Mimetic Model in Human iPS Cell-Derived Insulin-Producing Cells and the Anti-Apoptotic Effect of GLP-1 Analogue.
Human and Animal Cells Acidic pH increases cGMP accumulation through the OGR1/phospholipase C/Ca(2+)/neuronal NOS pathway in N1E-115 neuronal cells.
Human and Animal Cells Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers.
Human and Animal Cells Inhibition of the PI3K/Akt/GSK3 pathway downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD downregulates DNA damage-induced Chk1 activation as well as G2/M arrest and prominently enhances induction of apoptosis.
Human and Animal Cells mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK3CA-mutant breast cancer.
Human and Animal Cells L1cam promotes tumor progression and metastasis and is an independent unfavorable prognostic factor in gastric cancer.