| RRC ID |
19389
|
| 著者 |
Donlea JM, Thimgan MS, Suzuki Y, Gottschalk L, Shaw PJ.
|
| タイトル |
Inducing sleep by remote control facilitates memory consolidation in Drosophila.
|
| ジャーナル |
Science
|
| Abstract |
Sleep is believed to play an important role in memory consolidation. We induced sleep on demand by expressing the temperature-gated nonspecific cation channel Transient receptor potential cation channel (UAS-TrpA1) in neurons, including those with projections to the dorsal fan-shaped body (FB). When the temperature was raised to 31°C, flies entered a quiescent state that meets the criteria for identifying sleep. When sleep was induced for 4 hours after a massed-training protocol for courtship conditioning that is not capable of inducing long-term memory (LTM) by itself, flies develop an LTM. Activating the dorsal FB in the absence of sleep did not result in the formation of LTM after massed training.
|
| 巻・号 |
332(6037)
|
| ページ |
1571-6
|
| 公開日 |
2011-6-24
|
| DOI |
10.1126/science.1202249
|
| PII |
332/6037/1571
|
| PMID |
21700877
|
| PMC |
PMC4064462
|
| MeSH |
Animals
Conditioning, Psychological
Drosophila / genetics
Drosophila / physiology*
Drosophila Proteins / genetics
Drosophila Proteins / metabolism
Female
Memory, Long-Term / physiology*
Models, Animal
Motor Activity
Neurons / physiology*
Presynaptic Terminals / physiology
Sleep / physiology*
Social Isolation
Temperature
Transcription Factors / genetics
Transcription Factors / metabolism
Transient Receptor Potential Channels / genetics
Transient Receptor Potential Channels / metabolism
|
| IF |
41.846
|
| 引用数 |
174
|
|
WOS 分野
|
NEUROSCIENCES
|
| リソース情報 |
| ショウジョウバエ |
DGRC#113956 (NP6510)
DGRC#105258 (NP6561) |
