論文 - 詳細
| RRC ID | 19389 |
|---|---|
| 著者 | Donlea JM, Thimgan MS, Suzuki Y, Gottschalk L, Shaw PJ. |
| タイトル | Inducing sleep by remote control facilitates memory consolidation in Drosophila. |
| ジャーナル | Science |
| Abstract |
Sleep is believed to play an important role in memory consolidation. We induced sleep on demand by expressing the temperature-gated nonspecific cation channel Transient receptor potential cation channel (UAS-TrpA1) in neurons, including those with projections to the dorsal fan-shaped body (FB). When the temperature was raised to 31°C, flies entered a quiescent state that meets the criteria for identifying sleep. When sleep was induced for 4 hours after a massed-training protocol for courtship conditioning that is not capable of inducing long-term memory (LTM) by itself, flies develop an LTM. Activating the dorsal FB in the absence of sleep did not result in the formation of LTM after massed training. |
| 巻・号 | 332(6037) |
| ページ | 1571-6 |
| 公開日 | 2011-6-24 |
| DOI | 10.1126/science.1202249 |
| PII | 332/6037/1571 |
| PMID | 21700877 |
| PMC | PMC4064462 |
| MeSH | Animals Conditioning, Psychological Drosophila / genetics Drosophila / physiology* Drosophila Proteins / genetics Drosophila Proteins / metabolism Female Memory, Long-Term / physiology* Models, Animal Motor Activity Neurons / physiology* Presynaptic Terminals / physiology Sleep / physiology* Social Isolation Temperature Transcription Factors / genetics Transcription Factors / metabolism Transient Receptor Potential Channels / genetics Transient Receptor Potential Channels / metabolism |
| IF | 41.846 |
| 引用数 | 174 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 49 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#113956 (NP6510) DGRC#105258 (NP6561) |