RRC ID 19955
Author Murakami M, Suzuki S, Itou Y, Kodani S, Ishida K.
Title New anabaenopeptins, potent carboxypeptidase-A inhibitors from the cyanobacterium Aphanizomenon flos-aquae.
Journal J. Nat. Prod.
Abstract Anabaenopeptins I (1) and J (2), two new ureido bond-containing cyclic peptides, were isolated from the cultured cyanobacterium Aphanizomenon flos-aquae (NIES-81) as potent carboxypeptidase-A (CPA) inhibitors. The gross structures of 1 and 2 were established by spectroscopic analysis, including the 2D NMR techniques. The absolute configurations of 1 and 2 were determined by spectral and chemical methods. Anabaenopeptins I and J inhibited CPA with IC(50) values of 5.2 and 7.6 ng/mL, respectively.
Volume 63(9)
Pages 1280-2
Published 2000-9
PII np000120k
PMID 11000037
MeSH Carboxypeptidases / antagonists & inhibitors* Carboxypeptidases A Cyanobacteria / chemistry* Enzyme Inhibitors / chemistry Enzyme Inhibitors / isolation & purification* Enzyme Inhibitors / pharmacology Peptides, Cyclic / chemistry Peptides, Cyclic / isolation & purification* Peptides, Cyclic / pharmacology Protein Conformation Spectrum Analysis
IF 3.885
Times Cited 37
WOS Category CHEMISTRY, MEDICINAL PHARMACOLOGY & PHARMACY PLANT SCIENCES
Resource
Algae NIES-81