| RRC ID |
19955
|
| 著者 |
Murakami M, Suzuki S, Itou Y, Kodani S, Ishida K.
|
| タイトル |
New anabaenopeptins, potent carboxypeptidase-A inhibitors from the cyanobacterium Aphanizomenon flos-aquae.
|
| ジャーナル |
J Nat Prod
|
| Abstract |
Anabaenopeptins I (1) and J (2), two new ureido bond-containing cyclic peptides, were isolated from the cultured cyanobacterium Aphanizomenon flos-aquae (NIES-81) as potent carboxypeptidase-A (CPA) inhibitors. The gross structures of 1 and 2 were established by spectroscopic analysis, including the 2D NMR techniques. The absolute configurations of 1 and 2 were determined by spectral and chemical methods. Anabaenopeptins I and J inhibited CPA with IC(50) values of 5.2 and 7.6 ng/mL, respectively.
|
| 巻・号 |
63(9)
|
| ページ |
1280-2
|
| 公開日 |
2000-9-1
|
| DOI |
10.1021/np000120k
|
| PII |
np000120k
|
| PMID |
11000037
|
| MeSH |
Carboxypeptidases / antagonists & inhibitors*
Carboxypeptidases A
Cyanobacteria / chemistry*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification*
Enzyme Inhibitors / pharmacology
Peptides, Cyclic / chemistry
Peptides, Cyclic / isolation & purification*
Peptides, Cyclic / pharmacology
Protein Conformation
Spectrum Analysis
|
| IF |
3.782
|
| 引用数 |
52
|
|
WOS 分野
|
CHEMISTRY, MEDICINAL
PHARMACOLOGY & PHARMACY
PLANT SCIENCES
|
| リソース情報 |
| 藻類 |
NIES-81 |
