RRC ID 1998
著者 Ozaki K, Inoue K, Sato H, Iida A, Ohnishi Y, Sekine A, Sato H, Odashiro K, Nobuyoshi M, Hori M, Nakamura Y, Tanaka T.
タイトル Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro.
ジャーナル Nature
Abstract Myocardial infarction (MI) has become one of the leading causes of death in the world. Its pathogenesis includes chronic formation of plaque inside the vessel wall of the coronary artery and acute rupture of the artery, implicating a number of inflammation-mediating molecules, such as the cytokine lymphotoxin-alpha (LTA). Functional variations in LTA are associated with susceptibility to MI. Here we show that LTA protein binds to galectin-2, a member of the galactose-binding lectin family. Our case-control association study in a Japanese population showed that a single nucleotide polymorphism in LGALS2 encoding galectin-2 is significantly associated with susceptibility to MI. This genetic substitution affects the transcriptional level of galectin-2 in vitro, potentially leading to altered secretion of LTA, which would then affect the degree of inflammation; however, its relevance to other populations remains to be clarified. Smooth muscle cells and macrophages in the human atherosclerotic lesions expressed both galectin-2 and LTA. Our findings thus suggest a link between the LTA cascade and the pathogenesis of MI.
巻・号 429(6987)
ページ 72-5
公開日 2004-5-6
DOI 10.1038/nature02502
PII nature02502
PMID 15129282
MeSH Case-Control Studies Galectin 2 / genetics* Galectin 2 / metabolism* Gene Expression Regulation Genetic Predisposition to Disease / genetics* Humans Inflammation / genetics Introns / genetics Japan Jurkat Cells Lymphotoxin-alpha / metabolism* Microtubules / metabolism Myocardial Infarction / genetics* Polymorphism, Single Nucleotide / genetics Protein Binding RNA, Small Interfering / genetics RNA, Small Interfering / metabolism Tubulin / metabolism Two-Hybrid System Techniques
IF 42.779
引用数 179
WOS 分野 GENETICS & HEREDITY
リソース情報
ヒト・動物細胞 Jurkat(RCB0806)