RRC ID 20090
Author Sano T, Usui T, Ueda K, Osada H, Kaya K.
Title Isolation of new protein phosphatase inhibitors from two cyanobacteria species, Planktothrix spp.
Journal J. Nat. Prod.
Abstract Two new protein phosphatase inhibitors, oscillamide B (1) and C (2), were isolated from the cyanobacteria Planktothrix (Oscillatoria) agardhii and P. rubescens. The structures of the inhibitors were elucidated by analysis of HRFABMS, 1D and 2D NMR spectra, and chemical degradation. These inhibitors are ureido-containing cyclic peptides and inhibited serine/threonine protein phosphatases PP1 and PP2A. The inhibitory activities were closely related to the Arg and N-Me-Hty residues in the peptides.
Volume 64(8)
Pages 1052-5
Published 2001-8
PII np0005356
PMID 11520225
MeSH Chromatography, High Pressure Liquid Cyanobacteria / chemistry* Enzyme Inhibitors / chemistry Enzyme Inhibitors / isolation & purification* Magnetic Resonance Spectroscopy Mass Spectrometry Molecular Structure Peptides, Cyclic / chemistry Peptides, Cyclic / isolation & purification* Phosphoprotein Phosphatases / antagonists & inhibitors* Phosphoprotein Phosphatases / metabolism Phosphorylation Substrate Specificity
IF 3.885
Times Cited 48
WOS Category CHEMISTRY, MEDICINAL PHARMACOLOGY & PHARMACY PLANT SCIENCES
Resource
Algae NIES-928 NIES-905