論文 - 詳細
| RRC ID | 2020 |
|---|---|
| 著者 | Ishizuka S, Yamaya M, Suzuki T, Takahashi H, Ida S, Sasaki T, Inoue D, Sekizawa K, Nishimura H, Sasaki H. |
| タイトル | Effects of rhinovirus infection on the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells. |
| ジャーナル | J Infect Dis |
| Abstract |
To examine the effects of rhinovirus (RV) infection on the adherence of Streptococcus pneumoniae to human tracheal epithelial cells, cells were infected with RV-14, and S. pneumoniae were added to the culture medium. The number of S. pneumoniae adhering to epithelial cells increased after RV infection. Y-24180, a specific inhibitor of the platelet-activating factor receptor (PAF-R); PAF; and the pyrrolidine derivative of dithiocarbamate, an inhibitor of transcription factor nuclear factor-kappaB (NF-kappaB), decreased the number of S. pneumoniae adhering to cells after RV-14 infection. RV-14 infection increased PAF-R expression and the activation of NF-kappaB and promoter-specific transcription factor 1. These findings suggest that RV-14 infection stimulates S. pneumoniae adhesion to airway epithelial cells via increases in PAF-Rs that are partly mediated through activation of transcription factors. Increased adherence of S. pneumoniae may be one of the reasons that pneumonia develops after RV infection. |
| 巻・号 | 188(12) |
| ページ | 1928-39 |
| 公開日 | 2003-12-15 |
| DOI | 10.1086/379833 |
| PII | JID30440 |
| PMID | 14673774 |
| MeSH | Bacterial Adhesion* Cells, Cultured Epithelial Cells / metabolism Epithelial Cells / microbiology Humans NF-kappa B / antagonists & inhibitors NF-kappa B / physiology Picornaviridae Infections* Platelet Activating Factor / antagonists & inhibitors Platelet Activating Factor / physiology Platelet Membrane Glycoproteins / antagonists & inhibitors Platelet Membrane Glycoproteins / metabolism Pneumococcal Infections / microbiology* Receptors, G-Protein-Coupled / antagonists & inhibitors Receptors, G-Protein-Coupled / metabolism Respiratory Mucosa / metabolism Respiratory Mucosa / microbiology Rhinovirus / pathogenicity* Streptococcus pneumoniae / pathogenicity Streptococcus pneumoniae / physiology* Time Factors Transcription Factors / physiology Virulence |
| IF | 5.022 |
| 引用数 | 114 |
| WOS 分野 | INFECTIOUS DISEASES MICROBIOLOGY IMMUNOLOGY |
| リソース情報 | |
| 遺伝子材料 | Human PAF receptor (RDB01622) |