Reference - Detail
|Author||Ishizuka S, Yamaya M, Suzuki T, Takahashi H, Ida S, Sasaki T, Inoue D, Sekizawa K, Nishimura H, Sasaki H.|
|Title||Effects of rhinovirus infection on the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells.|
|Journal||J. Infect. Dis.|
To examine the effects of rhinovirus (RV) infection on the adherence of Streptococcus pneumoniae to human tracheal epithelial cells, cells were infected with RV-14, and S. pneumoniae were added to the culture medium. The number of S. pneumoniae adhering to epithelial cells increased after RV infection. Y-24180, a specific inhibitor of the platelet-activating factor receptor (PAF-R); PAF; and the pyrrolidine derivative of dithiocarbamate, an inhibitor of transcription factor nuclear factor-kappaB (NF-kappaB), decreased the number of S. pneumoniae adhering to cells after RV-14 infection. RV-14 infection increased PAF-R expression and the activation of NF-kappaB and promoter-specific transcription factor 1. These findings suggest that RV-14 infection stimulates S. pneumoniae adhesion to airway epithelial cells via increases in PAF-Rs that are partly mediated through activation of transcription factors. Increased adherence of S. pneumoniae may be one of the reasons that pneumonia develops after RV infection.
|MeSH||Bacterial Adhesion* Cells, Cultured Epithelial Cells / metabolism Epithelial Cells / microbiology Humans NF-kappa B / antagonists & inhibitors NF-kappa B / physiology Picornaviridae Infections* Platelet Activating Factor / antagonists & inhibitors Platelet Activating Factor / physiology Platelet Membrane Glycoproteins / antagonists & inhibitors Platelet Membrane Glycoproteins / metabolism Pneumococcal Infections / microbiology* Receptors, G-Protein-Coupled / antagonists & inhibitors Receptors, G-Protein-Coupled / metabolism Respiratory Mucosa / metabolism Respiratory Mucosa / microbiology Rhinovirus / pathogenicity* Streptococcus pneumoniae / pathogenicity Streptococcus pneumoniae / physiology* Time Factors Transcription Factors / physiology Virulence|
|WOS Category||INFECTIOUS DISEASES MICROBIOLOGY IMMUNOLOGY|
|DNA material||Human PAF receptor (RDB01622)|