RRC ID 2020
Author Ishizuka S, Yamaya M, Suzuki T, Takahashi H, Ida S, Sasaki T, Inoue D, Sekizawa K, Nishimura H, Sasaki H.
Title Effects of rhinovirus infection on the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells.
Journal J. Infect. Dis.
Abstract To examine the effects of rhinovirus (RV) infection on the adherence of Streptococcus pneumoniae to human tracheal epithelial cells, cells were infected with RV-14, and S. pneumoniae were added to the culture medium. The number of S. pneumoniae adhering to epithelial cells increased after RV infection. Y-24180, a specific inhibitor of the platelet-activating factor receptor (PAF-R); PAF; and the pyrrolidine derivative of dithiocarbamate, an inhibitor of transcription factor nuclear factor-kappaB (NF-kappaB), decreased the number of S. pneumoniae adhering to cells after RV-14 infection. RV-14 infection increased PAF-R expression and the activation of NF-kappaB and promoter-specific transcription factor 1. These findings suggest that RV-14 infection stimulates S. pneumoniae adhesion to airway epithelial cells via increases in PAF-Rs that are partly mediated through activation of transcription factors. Increased adherence of S. pneumoniae may be one of the reasons that pneumonia develops after RV infection.
Volume 188(12)
Pages 1928-39
Published 2003-12-15
DOI 10.1086/379833
PII JID30440
PMID 14673774
MeSH Bacterial Adhesion* Cells, Cultured Epithelial Cells / metabolism Epithelial Cells / microbiology Humans NF-kappa B / antagonists & inhibitors NF-kappa B / physiology Picornaviridae Infections* Platelet Activating Factor / antagonists & inhibitors Platelet Activating Factor / physiology Platelet Membrane Glycoproteins / antagonists & inhibitors Platelet Membrane Glycoproteins / metabolism Pneumococcal Infections / microbiology* Receptors, G-Protein-Coupled / antagonists & inhibitors Receptors, G-Protein-Coupled / metabolism Respiratory Mucosa / metabolism Respiratory Mucosa / microbiology Rhinovirus / pathogenicity* Streptococcus pneumoniae / pathogenicity Streptococcus pneumoniae / physiology* Time Factors Transcription Factors / physiology Virulence
IF 5.186
Times Cited 80
DNA material Human PAF receptor (RDB01622)