論文 - 詳細
| RRC ID | 20983 |
|---|---|
| 著者 | Wang L, Lu Y, Guan H, Jiang D, Guan Y, Zhang X, Nakano H, Zhou Y, Zhang Y, Yang L, Li H. |
| タイトル | Tumor necrosis factor receptor-associated factor 5 is an essential mediator of ischemic brain infarction. |
| ジャーナル | J Neurochem |
| Abstract |
Tumor necrosis factor receptor-associated factor 5 (TRAF5) is an adaptor protein of the tumor necrosis factor (TNF) receptor superfamily and the interleukin-1 receptor/Toll-like receptor superfamily and plays important roles in regulating multiple signaling pathways. This study was conducted to investigate the role of TRAF5 in the context of brain ischemia/reperfusion (I/R) injury. Transient occlusion of the middle cerebral artery was performed on TRAF5 knockout mice (KO), neuron-specific TRAF5 transgene (TG), and the appropriate controls. Compared with the WT mice, the TRAF5 KO mice showed lower infarct volumes and better outcomes in the neurological tests. A low neuronal apoptosis level, an attenuated blood-brain barrier (BBB) disruption and an inhibited inflammatory response were exhibited in TRAF5 KO mice. TRAF5 TG mice exhibited an opposite phenotype. Moreover, the Akt/FoxO1 signaling pathway was enhanced in the ischemic brains of the TRAF5 KO mice. These results provide the first demonstration that TRAF5 is a critical mediator of I/R injury in an experimental stroke model. The Akt /FoxO1 signaling pathway probably plays an important role in the biological function of TRAF5 in this model. |
| 巻・号 | 126(3) |
| ページ | 400-14 |
| 公開日 | 2013-8-1 |
| DOI | 10.1111/jnc.12207 |
| PMID | 23413803 |
| MeSH | Animals Blotting, Western Brain Infarction / metabolism* Brain Infarction / pathology Brain Ischemia / metabolism Brain Ischemia / pathology Disease Models, Animal Fluorescent Antibody Technique In Situ Nick-End Labeling Male Mice Mice, Inbred C57BL Mice, Knockout Real-Time Polymerase Chain Reaction Reperfusion Injury / metabolism Signal Transduction / physiology* TNF Receptor-Associated Factor 5 / metabolism* |
| IF | 4.066 |
| 引用数 | 25 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC02573 |