論文 - 詳細
| RRC ID | 21774 |
|---|---|
| 著者 | Kubo T, Kato N, Hosoya K, Kaya K. |
| タイトル | Effective determination method for a cyanobacterial neurotoxin, beta-N-methylamino-L-alanine. |
| ジャーナル | Toxicon |
| Abstract |
We developed a simple and effective analysis procedure that includes pretreatment and determination methods for beta-N-methylamino-l-alanine (BMAA), a cyanobacterial neurotoxin. BMAA may be produced by all known groups of cyanobacteria living in freshwater as well as marine environments. In this paper, we report a novel determination method for BMAA. A cation-exchange resin was effective for the selective concentration of BMAA from cyanobacterial extracts and yielded a high recovery rate. Moreover, liquid chromatography (LC)-electrospray ionization mass spectrometry with a hydrophilic LC column was effective for determining BMAA levels. The quantitation limit for BMAA based on selected ion monitoring (SIM) was determined as 0.5 ng at a signal/noise ratio of 5. |
| 巻・号 | 51(7) |
| ページ | 1264-8 |
| 公開日 | 2008-6-1 |
| DOI | 10.1016/j.toxicon.2008.02.015 |
| PII | S0041-0101(08)00073-1 |
| PMID | 18407310 |
| MeSH | Amino Acids, Diamino / analysis* Amino Acids, Diamino / chemistry Cation Exchange Resins Chromatography, High Pressure Liquid Cyanobacteria* Cyanobacteria Toxins Excitatory Amino Acid Agonists / analysis* Excitatory Amino Acid Agonists / chemistry Neurotoxins / analysis* Neurotoxins / chemistry Spectrometry, Mass, Electrospray Ionization Water Pollutants, Chemical / analysis Water Pollutants, Chemical / chemistry |
| IF | 2.201 |
| 引用数 | 48 |
| WOS 分野 | PHARMACOLOGY & PHARMACY TOXICOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 藻類 | NIES-88 |