論文 - 詳細
| RRC ID | 21815 |
|---|---|
| 著者 | Pai TP, Chen CC, Lin HH, Chin AL, Lai JS, Lee PT, Tully T, Chiang AS. |
| タイトル | Drosophila ORB protein in two mushroom body output neurons is necessary for long-term memory formation. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Memory is initially labile and gradually consolidated over time through new protein synthesis into a long-lasting stable form. Studies of odor-shock associative learning in Drosophila have established the mushroom body (MB) as a key brain structure involved in olfactory long-term memory (LTM) formation. Exactly how early neural activity encoded in thousands of MB neurons is consolidated into protein-synthesis-dependent LTM remains unclear. Here, several independent lines of evidence indicate that changes in two MB vertical lobe V3 (MB-V3) extrinsic neurons are required and contribute to an extended neural network involved in olfactory LTM: (i) inhibiting protein synthesis in MB-V3 neurons impairs LTM; (ii) MB-V3 neurons show enhanced neural activity after spaced but not massed training; (iii) MB-V3 dendrites, synapsing with hundreds of MB α/β neurons, exhibit dramatic structural plasticity after removal of olfactory inputs; (iv) neurotransmission from MB-V3 neurons is necessary for LTM retrieval; and (v) RNAi-mediated down-regulation of oo18 RNA-binding protein (involved in local regulation of protein translation) in MB-V3 neurons impairs LTM. Our results suggest a model of long-term memory formation that includes a systems-level consolidation process, wherein an early, labile olfactory memory represented by neural activity in a sparse subset of MB neurons is converted into a stable LTM through protein synthesis in dendrites of MB-V3 neurons synapsed onto MB α lobes. |
| 巻・号 | 110(19) |
| ページ | 7898-903 |
| 公開日 | 2013-5-7 |
| DOI | 10.1073/pnas.1216336110 |
| PII | 1216336110 |
| PMID | 23610406 |
| PMC | PMC3651462 |
| MeSH | Animals Crosses, Genetic Cyclic AMP Response Element-Binding Protein / metabolism Drosophila Proteins / metabolism Drosophila Proteins / physiology* Drosophila melanogaster / genetics Drosophila melanogaster / physiology* Fragile X Mental Retardation Protein / metabolism Gene Expression Regulation* Memory, Long-Term / physiology* Models, Neurological Mushroom Bodies / metabolism Mushroom Bodies / physiology* Neurons / metabolism RNA-Binding Proteins / metabolism RNA-Binding Proteins / physiology* Synaptic Transmission Transcription Factors / metabolism mRNA Cleavage and Polyadenylation Factors / metabolism |
| IF | 9.412 |
| 引用数 | 64 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 10868R-1 10868R-5 |