論文 - 詳細
| RRC ID | 21838 |
|---|---|
| 著者 | Loncle N, Williams DW. |
| タイトル | An interaction screen identifies headcase as a regulator of large-scale pruning. |
| ジャーナル | J Neurosci |
| Abstract |
Large-scale pruning, the removal of long neuronal processes, is deployed widely within the developing nervous system and is essential for proper circuit formation. In Drosophila the dendrites of the class IV dendritic arborization sensory neuron ddaC undergo large-scale pruning by local degeneration controlled by the steroid hormone ecdysone. The molecular mechanisms that control such events are largely unknown. To identify new molecules that orchestrate this developmental degeneration, we performed a genetic interaction screen. Our approach combines the strength of Drosophila forward genetics with detailed in vivo imaging of ddaC neurons. This screen allowed us to identify headcase (hdc) as a new gene involved in dendrite pruning. hdc is evolutionarily conserved, but the protein's function is unknown. Here we show that hdc is expressed just before metamorphosis in sensory neurons that undergo remodeling. hdc is required in a cell-autonomous manner to control dendrite severing, the first phase of pruning. Our epistasis experiments with known regulators of dendrite pruning reveal hdc as a founding member of a new pathway downstream of ecdysone signaling. |
| 巻・号 | 32(48) |
| ページ | 17086-96 |
| 公開日 | 2012-11-28 |
| DOI | 10.1523/JNEUROSCI.1391-12.2012 |
| PII | 32/48/17086 |
| PMID | 23197702 |
| PMC | PMC3541709 |
| MeSH | Animals Dendrites / genetics Dendrites / metabolism* Drosophila Drosophila Proteins / genetics Drosophila Proteins / metabolism* Ecdysone / genetics Ecdysone / metabolism* Female Gene Expression Regulation, Developmental Male Metamorphosis, Biological / physiology Sensory Receptor Cells / metabolism* Signal Transduction / genetics |
| IF | 5.674 |
| 引用数 | 30 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 15532R-2 |