Reference - Detail
| RRC ID | 21864 |
|---|---|
| Author | Baek SH, Cho HW, Kwon YC, Lee JH, Kim MJ, Lee H, Choe KM. |
| Title | Requirement for Pak3 in Rac1-induced organization of actin and myosin during Drosophila larval wound healing. |
| Journal | FEBS Lett |
| Abstract |
Rho-family small GTPases regulate epithelial cell sheet migration by organizing actin and myosin during wound healing. Here, we report that Pak3, but not Pak1, is a downstream target protein for Rac1 in wound closure of the Drosophila larval epidermis. Pak3-deficient larvae failed to close a wound hole and this defect was not rescued by Pak1 expression, indicating differential functions of the two proteins. Pak3 localized to the wound margin, which selectively required Rac1. Pak3-deficient larvae showed severe defects in actin-myosin organization at the wound margin and in submarginal cells, which was reminiscent of the phenotypes of Rac1-deficient larvae. These results suggest that Pak3 specifically mediates Rac1 signaling in organizing actin and myosin during Drosophila epidermal wound healing. |
| Volume | 586(6) |
| Pages | 772-7 |
| Published | 2012-3-23 |
| DOI | 10.1016/j.febslet.2012.01.061 |
| PII | S0014-5793(12)00110-X |
| PMID | 22449966 |
| MeSH | Actins / metabolism* Animals Drosophila Proteins / metabolism* Drosophila melanogaster / physiology* Epidermis / pathology Epidermis / physiology Larva / anatomy & histology Larva / physiology* Myosins / metabolism* Recombinant Fusion Proteins / genetics Recombinant Fusion Proteins / metabolism Wound Healing / physiology p21-Activated Kinases / genetics p21-Activated Kinases / metabolism* rac1 GTP-Binding Protein / genetics rac1 GTP-Binding Protein / metabolism* |
| IF | 3.057 |
| Times Cited | 14 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | 14895R-1 2248R-2 9774R-2 18255R-3 |