Reference - Detail
RRC ID | 21875 |
---|---|
Author | Rogulja D, Young MW. |
Title | Control of sleep by cyclin A and its regulator. |
Journal | Science |
Abstract |
How and why the brain reversibly switches from a waking to a sleep state remain among the most intriguing questions in biology. We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster. Reducing the abundance of CycA in neurons delayed the wake-sleep transition, caused multiple arousals from sleep, and reduced the homeostatic response to sleep deprivation. CycA is expressed in ~40 to 50 neurons in the adult brain, most of which are intermingled with circadian clock neurons, suggesting functional interactions among neurons controlling sleep and circadian behavior. |
Volume | 335(6076) |
Pages | 1617-21 |
Published | 2012-3-30 |
DOI | 10.1126/science.1212476 |
PII | 335/6076/1617 |
PMID | 22461610 |
PMC | PMC3380085 |
MeSH | Animals Brain / cytology Brain / metabolism Cell Cycle Proteins / genetics Cell Cycle Proteins / metabolism* Circadian Clocks Cyclin A / genetics Cyclin A / metabolism* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / genetics Drosophila melanogaster / physiology* Female Genes, Insect Homeostasis Male Neurons / metabolism* Neuropeptides / genetics Neuropeptides / metabolism Period Circadian Proteins / genetics Period Circadian Proteins / metabolism Phenotype RNA Interference Sleep / physiology* Sleep Deprivation |
IF | 41.846 |
Times Cited | 48 |
WOS Category | MULTIDISCIPLINARY SCIENCES |
Resource | |
Drosophila | 10800R-1 5940R-1 |