Reference - Detail
| RRC ID | 21965 |
|---|---|
| Author | Kurusu M, Cording A, Taniguchi M, Menon K, Suzuki E, Zinn K. |
| Title | A screen of cell-surface molecules identifies leucine-rich repeat proteins as key mediators of synaptic target selection. |
| Journal | Neuron |
| Abstract |
In Drosophila embryos and larvae, a small number of identified motor neurons innervate body wall muscles in a highly stereotyped pattern. Although genetic screens have identified many proteins that are required for axon guidance and synaptogenesis in this system, little is known about the mechanisms by which muscle fibers are defined as targets for specific motor axons. To identify potential target labels, we screened 410 genes encoding cell-surface and secreted proteins, searching for those whose overexpression on all muscle fibers causes motor axons to make targeting errors. Thirty such genes were identified, and a number of these were members of a large gene family encoding proteins whose extracellular domains contain leucine-rich repeat (LRR) sequences, which are protein interaction modules. By manipulating gene expression in muscle 12, we showed that four LRR proteins participate in the selection of this muscle as the appropriate synaptic target for the RP5 motor neuron. |
| Volume | 59(6) |
| Pages | 972-85 |
| Published | 2008-9-25 |
| DOI | 10.1016/j.neuron.2008.07.037 |
| PII | S0896-6273(08)00668-5 |
| PMID | 18817735 |
| PMC | PMC2630283 |
| MeSH | Animals Axons / metabolism Cell Movement / physiology Databases, Protein Drosophila / growth & development Drosophila / metabolism* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Gene Expression Profiling Growth Cones / metabolism* Insulin-Like Growth Factor Binding Proteins / metabolism Larva / metabolism Leucine Membrane Proteins / genetics Membrane Proteins / metabolism Models, Neurological Motor Neurons / cytology Motor Neurons / metabolism* Muscle Fibers, Skeletal / cytology Muscle Fibers, Skeletal / metabolism Muscles / innervation* Muscles / metabolism Neuromuscular Junction / growth & development* Neuromuscular Junction / metabolism Protein Structure, Tertiary / physiology RNA, Messenger / analysis Repetitive Sequences, Amino Acid |
| IF | 14.415 |
| Times Cited | 79 |
| WOS Category | NEUROSCIENCES |
| Resource | |
| Drosophila | 14351R-2 14351R-3 |