RRC ID 21979
Author Bajzek C, Rice AM, Andreazza S, Dushay MS.
Title Coagulation and survival in Drosophila melanogaster fondue mutants.
Journal J. Insect Physiol.
Abstract Drosophila larval coagulation factors have been identified in vitro. Better understanding of insect hemolymph coagulation calls for experiments in vivo. We have characterized a fondue (fon) mutation and null alleles isolated by imprecise excision of a transposable element. Loss of fon was pupal lethal, but adults could be recovered by expressing the UAS::fonGFP construct of Lindgren et al. (2008). Despite their lethality, fon mutations did not affect larval survival after wounding either when tested alone or in combination with a mutation in the hemolectin clotting factor gene. This reinforces the idea of redundant hemostatic mechanisms in Drosophila larvae, and independent pleiotropic functions of the fondue protein in coagulation and a vital process in metamorphosis.
Volume 58(10)
Pages 1376-81
Published 2012-10
DOI 10.1016/j.jinsphys.2012.07.013
PII S0022-1910(12)00188-6
PMID 22885376
MeSH Animals Blood Proteins / genetics* Drosophila Proteins / genetics* Drosophila melanogaster / genetics Drosophila melanogaster / physiology* Female Hemolymph / physiology* Hemostasis* Larva / physiology Male Mutation
IF 2.733
Times Cited 4