論文 - 詳細
| RRC ID | 21988 |
|---|---|
| 著者 | Kanesaki T, Hirose S, Grosshans J, Fuse N. |
| タイトル | Heterotrimeric G protein signaling governs the cortical stability during apical constriction in Drosophila gastrulation. |
| ジャーナル | Mech Dev |
| Abstract |
During gastrulation in Drosophila melanogaster, coordinated apical constriction of the cellular surface drives invagination of the mesoderm anlage. Forces generated by the cortical cytoskeletal network have a pivotal role in this cellular shape change. Here, we show that the organisation of cortical actin is essential for stabilisation of the cellular surface against contraction. We found that mutation of genes related to heterotrimeric G protein (HGP) signaling, such as Gβ13F, Gγ1, and ric-8, results in formation of blebs on the ventral cellular surface. The formation of blebs is caused by perturbation of cortical actin and induced by local surface contraction. HGP signaling mediated by two Gα subunits, Concertina and G-iα65A, constitutively regulates actin organisation. We propose that the organisation of cortical actin by HGP is required to reinforce the cortex so that the cells can endure hydrostatic stress during tissue folding. |
| 巻・号 | 130(2-3) |
| ページ | 132-42 |
| 公開日 | 2013-2-1 |
| DOI | 10.1016/j.mod.2012.10.001 |
| PII | S0925-4773(12)00096-2 |
| PMID | 23085574 |
| MeSH | Actins / metabolism Animals Blastoderm / cytology Cell Membrane / metabolism Cytoplasm / physiology Drosophila Proteins / physiology Drosophila melanogaster / cytology Drosophila melanogaster / embryology* Drosophila melanogaster / metabolism Female Gastrulation* Guanine Nucleotide Exchange Factors / physiology Heterotrimeric GTP-Binding Proteins / metabolism* Mesoderm / cytology Mesoderm / embryology Microscopy, Electron, Scanning Pressure Signal Transduction* |
| IF | 2.126 |
| 引用数 | 14 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |