RRC ID 21989
Author Takahashi KH.
Title Multiple capacitors for natural genetic variation in Drosophila melanogaster.
Journal Mol. Ecol.
Abstract Cryptic genetic variation (CGV) or a standing genetic variation that is not ordinarily expressed as a phenotype is released when the robustness of organisms is impaired under environmental or genetic perturbations. Evolutionary capacitors modulate the amount of genetic variation exposed to natural selection and hidden cryptically; they have a fundamental effect on the evolvability of traits on evolutionary timescales. In this study, I have demonstrated the effects of multiple genomic regions of Drosophila melanogaster on CGV in wing shape. I examined the effects of 61 genomic deficiencies on quantitative and qualitative natural genetic variation in the wing shape of D. melanogaster. I have identified 10 genomic deficiencies that do not encompass a known candidate evolutionary capacitor, Hsp90, exposing natural CGV differently depending on the location of the deficiencies in the genome. Furthermore, five genomic deficiencies uncovered qualitative CGV in wing morphology. These findings suggest that CGV in wing shape of wild-type D. melanogaster is regulated by multiple capacitors with divergent functions. Future analysis of genes encompassed by these genomic regions would help elucidate novel capacitor genes and better understand the general features of capacitors regarding natural genetic variation.
Volume 22(5)
Pages 1356-65
Published 2013-3
DOI 10.1111/mec.12091
PMID 23110557
MeSH Animals Drosophila melanogaster / genetics* Environment Evolution, Molecular Female Genetic Variation* Genotype HSP90 Heat-Shock Proteins / genetics Male Phenotype Selection, Genetic Wings, Animal / anatomy & histology
IF 6.131
Times Cited 17
WOS Category ECOLOGY EVOLUTIONARY BIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY
Resource
Drosophila 61 DrosDel isogenic deficiency strains Df(2L)ED1164 (DGRC#150313) Df(2L)ED1183 (DGRC#150314) Df(2L)ED1186 (DGRC#150109) Df(2L)ED1196 (DGRC#150111) Df(2L)ED1317 (DGRC#150409) Df(2L)ED13216 (DGRC#150058) Df(2L)ED1454 (DGRC#150021) Df(2L)ED2809 (DGRC#150415) Df(2L)ED3 (DGRC#130378 or DGRC#150222) Df(2L)ED373 (DGRC#150287) Df(2L)ED463 (DGRC#150079) Df(2L)ED4651 (DGRC#150040) Df(2L)ED692 (DGRC#150393) Df(2L)ED776 (DGRC#150301) Df(2L)ED778 (DGRC#150398) Df(2R)ED1552 (DGRC#150410) Df(2R)ED1735 (DGRC#150027) Df(2R)ED1742 (DGRC#150028) Df(2R)ED1770 (DGRC#150510) Df(2R)ED1791 (DGRC#150124) Df(2R)ED2219 (DGRC#150031) Df(2R)ED2436 (DGRC#150035) Df(2R)ED3610 (DGRC#150126) Df(2R)ED3683 (DGRC#150039) Df(2R)ED3952 (DGRC#150130) Df(2R)ED9045 (DGRC#150263) Df(3L)ED207 (DGRC#150275) Df(3L)ED223 (DGRC#150280) Df(3L)ED225 (DGRC#150282) Df(3L)ED228 (DGRC#150283) Df(3L)ED230 (DGRC#150073) Df(3L)ED4341 (DGRC#150321 or DGRC#150425) Df(3L)ED4421 (DGRC#150230) Df(3L)ED4543 (DGRC#150434) Df(3L)ED4606 (DGRC#150324) Df(3L)ED4685 (DGRC#150436) Df(3L)ED4858 (DGRC#150232) Df(3L)ED4858 (DGRC#150233) Df(3L)ED4978 (DGRC#150442) Df(3L)ED5013 (DGRC#150235) Df(3R)ED10556 (DGRC#150357) Df(3R)ED10564 (DGRC#150360) Df(3R)ED10566 (DGRC#150361) Df(3R)ED10811 (DGRC#150267) Df(3R)ED10893 (DGRC#150362) Df(3R)ED13102 (DGRC#150484) Df(3R)ED5046 (DGRC#150446) Df(3R)ED5100 (DGRC#150237) Df(3R)ED5511 (DGRC#150487) Df(3R)ED5514 (DGRC#150152) Df(3R)ED5518 (DGRC#150153) Df(3R)ED5657 (DGRC#150330) Df(3R)ED5660 (DGRC#150331) Df(3R)ED5662 (DGRC#150332) Df(3R)ED5664 (DGRC#150333) Df(3R)ED5688 (DGRC#150334) Df(3R)ED5807 (DGRC#150246) Df(3R)ED5911 (DGRC#150047) Df(3R)ED6058 (DGRC#150251) Df(3R)ED6103 (DGRC#150050) Df(3R)ED6119 (DGRC#150338) Df(3R)ED6316 (DGRC#150475)