RRC ID 22025
Author Zhang X, Ren Q, Guo A.
Title Parallel pathways for cross-modal memory retrieval in Drosophila.
Journal J Neurosci
Abstract Memory-retrieval processing of cross-modal sensory preconditioning is vital for understanding the plasticity underlying the interactions between modalities. As part of the sensory preconditioning paradigm, it has been hypothesized that the conditioned response to an unreinforced cue depends on the memory of the reinforced cue via a sensory link between the two cues. To test this hypothesis, we studied cross-modal memory-retrieval processing in a genetically tractable model organism, Drosophila melanogaster. By expressing the dominant temperature-sensitive shibire(ts1) (shi(ts1)) transgene, which blocks synaptic vesicle recycling of specific neural subsets with the Gal4/UAS system at the restrictive temperature, we specifically blocked visual and olfactory memory retrieval, either alone or in combination; memory acquisition remained intact for these modalities. Blocking the memory retrieval of the reinforced olfactory cues did not impair the conditioned response to the unreinforced visual cues or vice versa, in contrast to the canonical memory-retrieval processing of sensory preconditioning. In addition, these conditioned responses can be abolished by blocking the memory retrieval of the two modalities simultaneously. In sum, our results indicated that a conditioned response to an unreinforced cue in cross-modal sensory preconditioning can be recalled through parallel pathways.
Volume 33(20)
Pages 8784-93
Published 2013-5-15
DOI 10.1523/JNEUROSCI.4631-12.2013
PII 33/20/8784
PMID 23678121
PMC PMC6618838
MeSH Animals Animals, Genetically Modified CD8 Antigens / genetics Conditioning, Psychological / physiology Cues Discrimination, Psychological / physiology Drosophila Drosophila Proteins / genetics Drosophila Proteins / metabolism Female Green Fluorescent Proteins / genetics Green Fluorescent Proteins / metabolism Memory, Short-Term / physiology Mental Recall / physiology* Models, Biological Mushroom Bodies / cytology Mushroom Bodies / physiology Neural Pathways / physiology* Neurons / physiology Smell / genetics Smell / physiology Statistics, Nonparametric Time Factors Transcription Factors / genetics Transcription Factors / metabolism Vision, Ocular / genetics Vision, Ocular / physiology
IF 5.674
Times Cited 10
Drosophila NP1131 (DGRC#103898) and c305a-Gal4