論文 - 詳細
RRC ID | 22707 |
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著者 | Messaritou G, Leptourgidou F, Franco M, Skoulakis EM. |
タイトル | A third functional isoform enriched in mushroom body neurons is encoded by the Drosophila 14-3-3zeta gene. |
ジャーナル | FEBS Lett |
Abstract |
14-3-3 proteins are highly conserved across eukaryotes, typically encoded by multiple genes in most species. Drosophila has only two such genes, 14-3-3zeta (leo), encoding two isoforms LEOI and LEOII, and 14-3-3epsilon. We report a bona fide third functional isoform encoded by leo divergent from the other two in structurally and functionally significant areas, thus increasing 14-3-3 diversity in Drosophila. Furthermore, we used a novel approach of spatially restricted leo abrogation by RNA-interference and revealed differential LEO distribution in adult heads, with LEOIII enrichment in neurons essential for learning and memory in Drosophila. |
巻・号 | 583(17) |
ページ | 2934-8 |
公開日 | 2009-9-3 |
DOI | 10.1016/j.febslet.2009.08.003 |
PII | S0014-5793(09)00613-9 |
PMID | 19665025 |
MeSH | 14-3-3 Proteins / genetics 14-3-3 Proteins / metabolism* Amino Acid Sequence Animals Brain / cytology Brain / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster* / anatomy & histology Drosophila melanogaster* / genetics Drosophila melanogaster* / metabolism Molecular Sequence Data Neurons / cytology Neurons / metabolism* Protein Isoforms / genetics Protein Isoforms / metabolism* Sequence Alignment |
IF | 3.057 |
引用数 | 11 |
WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
リソース情報 | |
ショウジョウバエ |