| RRC ID |
2392
|
| 著者 |
Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N.
|
| タイトル |
The role of autophagy during the early neonatal starvation period.
|
| ジャーナル |
Nature
|
| Abstract |
At birth the trans-placental nutrient supply is suddenly interrupted, and neonates face severe starvation until supply can be restored through milk nutrients. Here, we show that neonates adapt to this adverse circumstance by inducing autophagy. Autophagy is the primary means for the degradation of cytoplasmic constituents within lysosomes. The level of autophagy in mice remains low during embryogenesis; however, autophagy is immediately upregulated in various tissues after birth and is maintained at high levels for 3-12 h before returning to basal levels within 1-2 days. Mice deficient for Atg5, which is essential for autophagosome formation, appear almost normal at birth but die within 1 day of delivery. The survival time of starved Atg5-deficient neonates (approximately 12 h) is much shorter than that of wild-type mice (approximately 21 h) but can be prolonged by forced milk feeding. Atg5-deficient neonates exhibit reduced amino acid concentrations in plasma and tissues, and display signs of energy depletion. These results suggest that the production of amino acids by autophagic degradation of 'self' proteins, which allows for the maintenance of energy homeostasis, is important for survival during neonatal starvation.
|
| 巻・号 |
432(7020)
|
| ページ |
1032-6
|
| 公開日 |
2004-12-23
|
| DOI |
10.1038/nature03029
|
| PII |
nature03029
|
| PMID |
15525940
|
| MeSH |
Animals
Animals, Newborn / metabolism*
Autophagy / physiology*
Autophagy-Related Protein 5
Cesarean Section
Energy Metabolism*
Female
Gene Deletion
Homeostasis
Lysosomes / metabolism
Mice
Mice, Knockout
Mice, Transgenic
Microtubule-Associated Proteins / deficiency
Microtubule-Associated Proteins / genetics
Microtubule-Associated Proteins / metabolism*
Pregnancy
Starvation / metabolism*
Survival Rate
Time Factors
|
| IF |
42.779
|
| 引用数 |
2003
|
|
WOS 分野
|
CELL BIOLOGY
|
| リソース情報 |
| 実験動物マウス |
RBRC00806 |
