論文 - 詳細
| RRC ID | 2406 |
|---|---|
| 著者 | Sugimoto M, Abe K. |
| タイトル | X chromosome reactivation initiates in nascent primordial germ cells in mice. |
| ジャーナル | PLoS Genet |
| Abstract |
During primordial germ cell (PGC) development, epigenetic reprogramming events represented by X chromosome reactivation and erasure of genomic imprinting are known to occur. Although precise timing is not given, X reactivation is thought to take place over a short period of time just before initiation of meiosis. Here, we show that the cessation of Xist expression commences in nascent PGCs, and re-expression of some X-linked genes begins in newly formed PGCs. The X reactivation process was not complete in E14.5 PGCs, indicating that X reactivation in developing PGCs occurs over a prolonged period. These results set the reactivation timing much earlier than previously thought and suggest that X reactivation may involve slow passive steps. |
| 巻・号 | 3(7) |
| ページ | e116 |
| 公開日 | 2007-7-1 |
| DOI | 10.1371/journal.pgen.0030116 |
| PII | 07-PLGE-RA-0234 |
| PMID | 17676999 |
| PMC | PMC1950944 |
| MeSH | Alleles Animals Epigenesis, Genetic Female Gene Expression Regulation, Developmental* Germ Cells / metabolism In Situ Hybridization, Fluorescence Kinetics Male Mice Mice, Transgenic Models, Genetic Time Factors X Chromosome* X Chromosome Inactivation* |
| IF | 5.175 |
| 引用数 | 121 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC00209 RBRC01739 |