RRC ID 2411
Author Nakao K, Morita R, Saji Y, Ishida K, Tomita Y, Ogawa M, Saitoh M, Tomooka Y, Tsuji T.
Title The development of a bioengineered organ germ method.
Journal Nat Methods
Abstract To bioengineer ectodermal organs such as teeth and whisker follicles, we developed a three-dimensional organ-germ culture method. The bioengineered tooth germ generated a structurally correct tooth, after both in vitro organ culture as well as transplantation under a tooth cavity in vivo, showing penetration of blood vessels and nerve fibers. Our method provides a substantial advance in the development of bioengineered organ replacement strategies and regenerative therapies.
Volume 4(3)
Pages 227-30
Published 2007-3-1
DOI 10.1038/nmeth1012
PII nmeth1012
PMID 17322892
MeSH Animals Bioartificial Organs* Biomedical Engineering / methods Cell Differentiation Cells, Cultured Epithelial Cells / physiology* Mesenchymal Stem Cells / cytology* Mice Organ Culture Techniques / methods Organogenesis / physiology* Tissue Engineering / methods* Tooth / cytology* Vibrissae / cytology*
IF 30.822
Times Cited 284
Mice RBRC00267