RRC ID 2450
Author Wada H, Tanaka H, Nakayama S, Iwasaki M, Okamoto H.
Title Frizzled3a and Celsr2 function in the neuroepithelium to regulate migration of facial motor neurons in the developing zebrafish hindbrain.
Journal Development
Abstract Migration of neurons from their birthplace to their final target area is a crucial step in brain development. Here, we show that expression of the off-limits/frizzled3a (olt/fz3a) and off-road/celsr2 (ord/celsr2) genes in neuroepithelial cells maintains the facial (nVII) motor neurons near the pial surface during their caudal migration in the zebrafish hindbrain. In the absence of olt/fz3a expression in the neuroepithelium, nVII motor neurons extended aberrant radial processes towards the ventricular surface and mismigrated radially to the dorsomedial part of the hindbrain. Our findings reveal a novel role for these genes, distinctive from their already known functions, in the regulation of the planar cell polarity (i.e. preventing integration of differentiated neurons into the neuroepithelial layer). This contrasts markedly with their reported role in reintegration of neuroepithelial daughter cells into the neuroepithelial layer after cell division.
Volume 133(23)
Pages 4749-59
Published 2006-12
DOI 10.1242/dev.02665
PII dev.02665
PMID 17079269
MeSH Animals Animals, Genetically Modified Cadherins / genetics* Cadherins / metabolism Cell Movement / genetics Cell Movement / physiology Frizzled Receptors / genetics* Frizzled Receptors / metabolism Gene Expression Regulation, Developmental Motor Neurons / cytology Motor Neurons / metabolism Mutation Neuroepithelial Cells / cytology Neuroepithelial Cells / metabolism Rhombencephalon / embryology* Rhombencephalon / metabolism Zebrafish / embryology* Zebrafish / genetics* Zebrafish / metabolism Zebrafish Proteins / genetics* Zebrafish Proteins / metabolism
IF 5.763
Times Cited 74
Zebrafish rw0 RIKEN WT (RW)