RRC ID 2451
Author Dufourcq P, Roussigné M, Blader P, Rosa F, Peyrieras N, Vriz S.
Title Mechano-sensory organ regeneration in adults: the zebrafish lateral line as a model.
Journal Mol Cell Neurosci
Abstract In this report, we present a study of regeneration of the lateral line, a collection of mechano-sensory organ, in the adult zebrafish caudal fin. As all neuromasts are innervated by axon fibers, neuronal regeneration is a key issue in the regenerating process. We first show that support cells from the last neuromast adjacent to the amputation plane divide and migrate to colonize the blastema in order to reform the missing part of the lateral line. We then show that nerve re-growth takes place later than neuromast progenitor cell migration. We also provide evidence that new growth cones form at the amputation plane and subsequently follow the migrating placode-like structure to re-innervate regenerated neuromasts as they differentiate. Altogether, our observations indicate that caudal lateral line regeneration is not a mere recapitulation of the ontogenic process.
Volume 33(2)
Pages 180-7
Published 2006-10-1
DOI 10.1016/j.mcn.2006.07.005
PII S1044-7431(06)00158-8
PMID 16949838
MeSH Animal Structures / cytology Animal Structures / innervation Animal Structures / physiology Animals Biomarkers Cell Division / physiology Models, Animal* Nerve Regeneration / physiology* Sensory Receptor Cells / cytology* Sensory Receptor Cells / physiology* Zebrafish / physiology*
IF 3.182
Times Cited 39
Zebrafish rw0