Reference - Detail
| RRC ID | 257 |
|---|---|
| Author | Watanabe T, Asaka S, Kitagawa D, Saito K, Kurashige R, Sasado T, Morinaga C, Suwa H, Niwa K, Henrich T, Hirose Y, Yasuoka A, Yoda H, Deguchi T, Iwanami N, Kunimatsu S, Osakada M, Loosli F, Quiring R, Carl M, Grabher C, Winkler S, Del Bene F, Wittbrodt J, Abe K, Takahama Y, Takahashi K, Katada T, Nishina H, Kondoh H, Furutani-Seiki M. |
| Title | Mutations affecting liver development and function in Medaka, Oryzias latipes, screened by multiple criteria. |
| Journal | Mech Dev |
| Abstract |
We report here mutations affecting various aspects of liver development and function identified by multiple assays in a systematic mutagenesis screen in Medaka. The 22 identified recessive mutations assigned to 19 complementation groups fell into five phenotypic groups. Group 1, showing defective liver morphogenesis, comprises mutations in four genes, which may be involved in the regulation of growth or patterning of the gut endoderm. Group 2 comprises mutations in three genes that affect the laterality of the liver; in kendama mutants of this group, the laterality of the heart and liver is uncoupled and randomized. Group 3 includes mutations in three genes altering bile color, indicative of defects in hemoglobin-bilirubin metabolism and globin synthesis. Group 4 consists of mutations in three genes, characterized by a decrease in the accumulation of fluorescent metabolite of a phospholipase A(2) substrate, PED6, in the gall bladder. Lipid metabolism or the transport of lipid metabolites may be affected by these mutations. Mutations in Groups 3 and 4 may provide animal models for relevant human diseases. Group 5 mutations in six genes affect the formation of endoderm, endodermal rods and hepatic bud from which the liver develops. These Medaka mutations, identified by morphological and metabolite marker screens, should provide clues to understanding molecular mechanisms underlying formation of a functional liver. |
| Volume | 121(7-8) |
| Pages | 791-802 |
| Published | 2004-7-1 |
| DOI | 10.1016/j.mod.2004.04.004 |
| PII | S092547730400084X |
| PMID | 15210186 |
| MeSH | Animals Body Patterning / genetics Endoderm Gallbladder / metabolism In Situ Hybridization Lipid Metabolism Liver / abnormalities Liver / embryology* Liver / physiology Mutation* Oryzias / embryology* Oryzias / genetics* Oryzias / physiology |
| IF | 2.126 |
| Times Cited | 30 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 9 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Medaka | ENU mutagenesis project |