RRC ID 2717
Author Sohda KY, Nagai K, Yamori T, Suzuki K, Tanaka A.
Title YM-216391, a novel cytotoxic cyclic peptide from Streptomyces nobilis. I. fermentation, isolation and biological activities.
Journal J Antibiot (Tokyo)
Abstract YM-216391, a novel cyclic peptide, was isolated from the cultured mycelium of Streptomyces nobilis JCM 4274. It was purified by solvent extraction, silica gel and ODS flash column chromatographies, followed by preparative HPLC. YM-216391 dose-dependently inhibited the growth of human cervical cancer HeLa S3 cells with an IC50 value of 14nM. YM-216391 also showed potent cytotoxic activity against a human cancer cell line panel.
Volume 58(1)
Pages 27-31
Published 2005-1-1
DOI 10.1038/ja.2005.2
PMID 15813177
MeSH Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification* Antineoplastic Agents / pharmacology Fermentation* HeLa Cells / drug effects Humans Molecular Structure Oxazoles / chemistry Oxazoles / isolation & purification* Oxazoles / pharmacology Peptides, Cyclic / chemistry Peptides, Cyclic / isolation & purification* Peptides, Cyclic / pharmacology Streptomyces
IF 2.668
Times Cited 8
Pathogenic microorganisms JCM 4274?