RRC ID 2717
著者 Sohda KY, Nagai K, Yamori T, Suzuki K, Tanaka A.
タイトル YM-216391, a novel cytotoxic cyclic peptide from Streptomyces nobilis. I. fermentation, isolation and biological activities.
ジャーナル J Antibiot (Tokyo)
Abstract YM-216391, a novel cyclic peptide, was isolated from the cultured mycelium of Streptomyces nobilis JCM 4274. It was purified by solvent extraction, silica gel and ODS flash column chromatographies, followed by preparative HPLC. YM-216391 dose-dependently inhibited the growth of human cervical cancer HeLa S3 cells with an IC50 value of 14nM. YM-216391 also showed potent cytotoxic activity against a human cancer cell line panel.
巻・号 58(1)
ページ 27-31
公開日 2005-1-1
DOI 10.1038/ja.2005.2
PMID 15813177
MeSH Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification* Antineoplastic Agents / pharmacology Fermentation* HeLa Cells / drug effects Humans Molecular Structure Oxazoles / chemistry Oxazoles / isolation & purification* Oxazoles / pharmacology Peptides, Cyclic / chemistry Peptides, Cyclic / isolation & purification* Peptides, Cyclic / pharmacology Streptomyces
IF 2.668
引用数 8
リソース情報
病原微生物 JCM 4274?