| RRC ID |
27775
|
| Author |
Zong J, Salim M, Zhou H, Bian ZY, Dai J, Yuan Y, Deng W, Zhang JY, Zhang R, Wu QQ, Tang QZ.
|
| Title |
NOD2 deletion promotes cardiac hypertrophy and fibrosis induced by pressure overload.
|
| Journal |
Lab Invest
|
| Abstract |
Nucleotide-binding oligomerization domain-2 (NOD2, also designated CARD15), a member of the NOD-leucine-rich repeat (LRR) protein family (also called the CATERPILLAR family), is upregulated in atheroma lesions and has an important role in regulating the intracellular recognition of bacterial components by immune cells. However, the effect of NOD2 on cardiac hypertrophy induced by a pathological stimulus has not been determined. Here, we investigated the effects of NOD2 deficiency on cardiac hypertrophy induced by aortic banding (AB) in mice. Cardiac hypertrophy was evaluated by echocardiographic, hemodynamic, pathological, and molecular analyses. NOD2 expression was upregulated in cardiomyocytes after aortic banding surgery in wild-type (WT) mice. NOD2 deficiency promoted cardiac hypertrophy and fibrosis 4 weeks after AB. Further, the enhanced activation of TLR4 and the MAPKs, NF-κB and TGF-β/Smad pathways were found in NOD2-knockout (KO) mice compared with WT mice. Our results suggest that NOD2 attenuates cardiac hypertrophy and fibrosis via regulation of multiple pathways.
|
| Volume |
93(10)
|
| Pages |
1128-36
|
| Published |
2013-10-1
|
| DOI |
10.1038/labinvest.2013.99
|
| PII |
labinvest201399
|
| PMID |
23958879
|
| MeSH |
Animals
Cardiomegaly / etiology
Cardiomegaly / metabolism*
Cardiomegaly / pathology
Cardiomegaly / physiopathology
Cell Nucleus
Disease Models, Animal*
Disease Progression
Fibrosis
Hypertension / physiopathology*
MAP Kinase Signaling System
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Myocardium / metabolism*
Myocardium / pathology
Nod2 Signaling Adaptor Protein / biosynthesis
Nod2 Signaling Adaptor Protein / genetics
Nod2 Signaling Adaptor Protein / metabolism*
Phosphorylation
Protein Processing, Post-Translational
Protein Transport
Random Allocation
Smad Proteins / metabolism
Toll-Like Receptor 4 / metabolism
Transcription Factor RelA / metabolism
Up-Regulation
|
| IF |
4.197
|
| Times Cited |
18
|
|
WOS Category
|
PATHOLOGY
MEDICINE, RESEARCH & EXPERIMENTAL
|
| Resource |
| Mice |
RBRC01869 |
