論文 - 詳細
RRC ID | 27917 |
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著者 | Svensk E, Ståhlman M, Andersson CH, Johansson M, Borén J, Pilon M. |
タイトル | PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans. |
ジャーナル | PLoS Genet |
Abstract |
C. elegans PAQR-2 is homologous to the insulin-sensitizing adiponectin receptors in mammals, and essential for adaptation to growth at 15°C, a low but usually acceptable temperature for this organism. By screening for novel paqr-2 suppressors, we identified mutations in genes involved in phosphatidylcholine synthesis (cept-1, pcyt-1 and sams-1) and fatty acid metabolism (ech-7, hacd-1, mdt-15, nhr-49 and sbp-1). We then show genetic evidence that paqr-2, phosphatidylcholines, sbp-1 and Δ9-desaturases form a cold adaptation pathway that regulates the increase in unsaturated fatty acids necessary to retain membrane fluidity at low temperatures. This model is supported by the observations that the paqr-2 suppressors normalize the levels of saturated fatty acids, and that low concentrations of detergents that increase membrane fluidity can rescue the paqr-2 mutant. |
巻・号 | 9(9) |
ページ | e1003801 |
公開日 | 2013-1-1 |
DOI | 10.1371/journal.pgen.1003801 |
PII | PGENETICS-D-13-00641 |
PMID | 24068966 |
PMC | PMC3772066 |
MeSH | Adaptation, Physiological / genetics* Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics* Cold Temperature Fatty Acids / chemistry Fatty Acids / metabolism* Insulin / metabolism Lipid Metabolism / genetics* Membrane Proteins / genetics* Mutation Phosphatidylcholines / metabolism Receptors, Adiponectin / genetics* Receptors, Adiponectin / metabolism Temperature |
IF | 5.175 |
引用数 | 44 |
WOS 分野 | GENETICS & HEREDITY |
リソース情報 | |
線虫 | tm3410 tm3262 tm1011 |