| RRC ID |
27919
|
| Author |
Niimi K, Han Y, Zhou Y, Yoshimoto T, Dai F, Teng X, Tian X, Li W, Takahashi E.
|
| Title |
Blockade of Cav2.1-mediated NMDA receptor signaling disrupts conditioned fear extinction.
|
| Journal |
Behav Brain Res
|
| Abstract |
Although fear extinction requires N-methyl-d-aspartate (NMDA) receptor signaling, Cav2.1-regulated synaptic function in extinction remains unknown. This study examined whether Cav2.1-mediated signaling plays role in consolidation of extinction. Wild-type mice received intracerebroventricular injection of Cav2.1 blocker (ω-agatoxin IVA, 4.0 pg/side) showed impaired extinction behavior and increased expression of CREB-dependent gene Arc in medial prefrontal cortex (mPFC). Intra-mPFC injections of NMDA receptor antagonist (MK-801, 0.5 μg/midline), which was ineffective in wild-type controls, blocked extinction in heterozygous rolling Nagoya (rol/+) mice carrying Cav2.1α1 gene mutation rol/+ mice. These results indicate that Cav2.1-mediated NMDA receptor signaling is functional pathway in mPFC-dependent fear extinction. Our results also indicate that the combination of pharmacological and genetic approaches can be used to study functional signaling pathways in neuronal circuits.
|
| Volume |
259
|
| Pages |
45-9
|
| Published |
2014-2-1
|
| DOI |
10.1016/j.bbr.2013.10.033
|
| PII |
S0166-4328(13)00648-7
|
| PMID |
24177210
|
| MeSH |
Analysis of Variance
Animals
Calcium Channel Blockers / pharmacology
Calcium Channels, N-Type / metabolism*
Conditioning, Psychological / drug effects
Conditioning, Psychological / physiology*
Dizocilpine Maleate / pharmacology
Dose-Response Relationship, Drug
Excitatory Amino Acid Antagonists / pharmacology
Extinction, Psychological / drug effects
Fear / drug effects
Fear / physiology*
Mice
Mice, Inbred C57BL
Prefrontal Cortex / drug effects
Prefrontal Cortex / metabolism
Receptors, N-Methyl-D-Aspartate / metabolism*
Signal Transduction / drug effects
Signal Transduction / physiology
Time Factors
omega-Agatoxin IVA / pharmacology
|
| IF |
2.977
|
| Times Cited |
2
|
|
WOS Category
|
NEUROSCIENCES
BEHAVIORAL SCIENCES
|
| Resource |
| Mice |
RBRC00388 |
