論文 - 詳細
| RRC ID | 28437 |
|---|---|
| 著者 | Nikaido T, Shimizu A, Ishida N, Sabe H, Teshigawara K, Maeda M, Uchiyama T, Yodoi J, Honjo T. |
| タイトル | Molecular cloning of cDNA encoding human interleukin-2 receptor. |
| ジャーナル | Nature |
| Abstract |
The human interleukin-2 (IL-2) receptor was purified by affinity chromatography using the anti-Tac monoclonal antibody, and its N-terminal amino acid sequence was determined. Complementary DNA clones were isolated and sequenced to reveal the primary structure of the IL-2 receptor precursor, which has 272 amino acid residues. The receptor is separated into two domains by a putative 19-residue transmembrane region. Two mRNAs (1.4 and 3.5 kilobases) hybridizing to the cDNA clone were found in human T cells bearing the IL-2 receptor. The cDNA directed synthesis of the IL-2 receptor in COS cells. |
| 巻・号 | 311(5987) |
| ページ | 631-5 |
| 公開日 | 1984-10-18 |
| DOI | 10.1038/311631a0 |
| PMID | 6090949 |
| MeSH | Amino Acid Sequence Base Sequence Cloning, Molecular* DNA / isolation & purification DNA / metabolism* DNA Restriction Enzymes Genes* Genetic Vectors Humans Nucleic Acid Hybridization Protein Biosynthesis RNA, Messenger / genetics Receptors, Antigen, T-Cell / genetics* Receptors, Immunologic / genetics* Receptors, Immunologic / isolation & purification Receptors, Interleukin-2 Transcription, Genetic |
| IF | 42.779 |
| 引用数 | 601 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 86 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 遺伝子材料 | pKCR. Tac-2A (RDB01171) |